TY - JOUR
T1 - Correlation between respiratory syncytial virus genotype and severity of illness
AU - Martinello, Richard A.
AU - Chen, Martin D.
AU - Weibel, Carla
AU - Kahn, Jeffrey
N1 - Funding Information:
Received 28 March 2002; revised 21 May 2002; electronically published 9 August 2002. Presented in part: 39th annual meeting of the Infectious Diseases Society of America, San Francisco, 25–28 October 2001 (abstract 410). Collection of clinical isolates and data was approved by the Yale University Human Investigation Committee. Financial support: National Institutes of Health (grants HD-27757 to J.S.K. and AI-07517 to R.A.M.); American Lung Association and American Lung Association of Connecticut (grant RG-042-N to J.S.K.). a Present affiliation: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Reprints or correspondence: Dr. Jeffrey S. Kahn, Dept. of Pediatrics, Div. of Infectious Diseases, Yale University School of Medicine, PO Box 208064, New Haven, CT 06520-8064 (jeffrey.kahn@yale.edu).
PY - 2002/9/15
Y1 - 2002/9/15
N2 - Respiratory syncytial virus (RSV) causes seasonal outbreaks of respiratory tract infections, but the viral factors associated with virulence remain unknown. To determine whether RSV genotype correlated with severity of illness, isolates were characterized by phylogenetic analysis of the RSV G gene, and a composite score was used to quantify severity of illness. During the 1998-1999 and 1999-2000 winter seasons, 137 subgroup A and 84 subgroup B isolates were identified. The severity of illness caused by subgroup A isolates did not differ from that caused by subgroup B isolates (P = .086). However, the GA3 clade was associated with significantly greater severity of illness, compared with clades GA2 (P = .004) and GA4 (P = .016). In a subpopulation of patients ≤24 months old who had no known risk factors for severe RSV disease, clade GA3 was again associated with greater severity of illness, compared with clade GA2 (P = .018). Severity of RSV infection is associated with RSV genotype.
AB - Respiratory syncytial virus (RSV) causes seasonal outbreaks of respiratory tract infections, but the viral factors associated with virulence remain unknown. To determine whether RSV genotype correlated with severity of illness, isolates were characterized by phylogenetic analysis of the RSV G gene, and a composite score was used to quantify severity of illness. During the 1998-1999 and 1999-2000 winter seasons, 137 subgroup A and 84 subgroup B isolates were identified. The severity of illness caused by subgroup A isolates did not differ from that caused by subgroup B isolates (P = .086). However, the GA3 clade was associated with significantly greater severity of illness, compared with clades GA2 (P = .004) and GA4 (P = .016). In a subpopulation of patients ≤24 months old who had no known risk factors for severe RSV disease, clade GA3 was again associated with greater severity of illness, compared with clade GA2 (P = .018). Severity of RSV infection is associated with RSV genotype.
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U2 - 10.1086/342414
DO - 10.1086/342414
M3 - Article
C2 - 12198620
AN - SCOPUS:0037105638
SN - 0022-1899
VL - 186
SP - 839
EP - 842
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -