Correction and optimization of a T2-based approach to map blood oxygenation in small cerebral veins

Lisa C. Krishnamurthy, Deng Mao, Kevin S. King, Hanzhang Lu

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Purpose Cerebral venous blood oxygenation (Yv) is an important biomarker in brain physiology and function. The present study proposes a procedure to provide a quantitative map of the brain's intravascular Yv. Theory and Methods The method is based on a pulse sequence, T2-Relaxation-Under-Phase-Contrast (TRU-PC) MRI, with postprocessing approaches to correct eddy-current effects. A complete scan protocol consists of four TRU-PC scans sensitized to large and small vessels with anterior-posterior and foot-head flow-encoding directions, and the data are analyzed conjunctively. Eddy-current correction was performed by fitting the tissue phase to a hyperplane, and then subtracting the eddy-current phase from the measured vessel phase. The reproducibility of the Yv-maps was examined in five participants. Sensitivity of the Yv map to a caffeine challenge was studied in another five participants. Results Removal of eddy-current induced artifact allowed for the correction of T2 measurements, as demonstrated in vivo and with simulation. A Yv-map depicting all vessels in the slice can be obtained with the proposed protocol. Test-retest variability of the Yv-map was 3.7 ± 1.2%. Yv reduction can be reliably detected (P < 0.001) following the caffeine ingestion. Conclusion With the proposed TRU-PC protocol and eddy-current correction procedure, an accurate, vessel-specific Yv map of the human brain can be obtained.

Original languageEnglish (US)
Pages (from-to)1100-1109
Number of pages10
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Mar 1 2016


  • CMRO
  • TRU-PC
  • blood oxygen saturation
  • eddy-currents
  • small vessel

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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