Coordinating expression of RNA binding proteins with their mRNA targets

Huifeng Jiang, Lin Xu, Zhe Wang, Jack Keene, Zhenglong Gu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory relationship between RBPs and their target mRNAs in yeast, we discovered that most RBP genes are co-regulated with their target genes, but the RBPs tend to dampen expression variation among their target mRNAs. We further examined a well-studied RBP gene, PUF3, and found that the protein decreases the variation of its target mRNAs by differentially affecting their decay. We also constructed a mathematical model to explain the relationship between RBPs and the expression of their target genes. Our results provided new insights into the functional importance of RBPs in coordinating the expression of their target genes.

Original languageEnglish (US)
Article number7175
JournalScientific reports
StatePublished - Nov 24 2014
Externally publishedYes

ASJC Scopus subject areas

  • General


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