Coordinating Cardiology clinics randomized trial of interventions to improve outcomes (COORDINATE) – Diabetes: rationale and design

Adam J. Nelson, Neha J. Pagidipati, Michelle D. Kelsey, Maddalena Ardissino, Vanita R. Aroda, Matthew A. Cavender, Renato D. Lopes, Hussein R. Al-Khalidi, Rogelio Braceras, Tanya Gaynor, Lisa A. Kaltenbach, Julienne K. Kirk, Ildiko Lingvay, Melissa L. Magwire, Emily C. O'Brien, Jonathan Pak, Rodica Pop-Busui, Caroline R. Richardson, Monica Levya, Cagri SenyucelLaura Webb, Darren K. McGuire, Jennifer B. Green, Christopher B. Granger

Research output: Contribution to journalArticlepeer-review


Several medications that are proven to reduce cardiovascular events exist for individuals with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease, however they are substantially underused in clinical practice. Clinician, patient, and system-level barriers all contribute to these gaps in care; yet, there is a paucity of high quality, rigorous studies evaluating the role of interventions to increase utilization. The COORDINATE-Diabetes trial randomized 42 cardiology clinics across the United States to either a multifaceted, site-specific intervention focused on evidence-based care for patients with T2DM or standard of care. The multifaceted intervention comprised the development of an interdisciplinary care pathway for each clinic, audit-and-feedback tools and educational outreach, in addition to patient-facing tools. The primary outcome is the proportion of individuals with T2DM prescribed three key classes of evidence-based medications (high-intensity statin, angiotensin converting enzyme inhibitor or angiotensin receptor blocker, and either a sodium/glucose cotransporter-2 inhibitor (SGLT-2i) inhibitor or glucagon-like peptide 1 receptor agonist (GLP-1RA) and will be assessed at least 6 months after participant enrollment. COORDINATE-Diabetes aims to identify strategies that improve the implementation and adoption of evidence-based therapies.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalAmerican heart journal
StatePublished - Feb 2023

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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