TY - JOUR
T1 - Convergent diversity-oriented synthesis of small-molecule hybrids
AU - Chen, Chuo
AU - Li, Xiaodong
AU - Neumann, Christopher S.
AU - Lo, Michael M C
AU - Schreiber, Stuart L.
PY - 2005/4/8
Y1 - 2005/4/8
N2 - (Chemical Equation Presented) Complex small-molecule libraries were constructed by a convergent approach with a short linear sequence: a 480-membered bridged-piperidine/fused-pyrrolidine hybrid library IV and a 384-membered spirocyclic-oxindole/fused-pyrrolidine hybrid library V from the sub-library II and the sublibraries I and III, respectively. II = R II-COOH.
AB - (Chemical Equation Presented) Complex small-molecule libraries were constructed by a convergent approach with a short linear sequence: a 480-membered bridged-piperidine/fused-pyrrolidine hybrid library IV and a 384-membered spirocyclic-oxindole/fused-pyrrolidine hybrid library V from the sub-library II and the sublibraries I and III, respectively. II = R II-COOH.
KW - Convergent synthesis
KW - Diversity-oriented synthesis
KW - Polycycles
KW - Small-molecule hybrids
KW - Solid-phase synthesis
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U2 - 10.1002/anie.200462798
DO - 10.1002/anie.200462798
M3 - Article
C2 - 15747386
AN - SCOPUS:17644400733
SN - 1433-7851
VL - 44
SP - 2249
EP - 2252
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 15
ER -