Contributions of the Extracellular Matrix to Tumorigenesis

Marie Schluterman Burdine, Rolf A. Brekken

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationTumor Microenvironment
PublisherJohn Wiley and Sons
Number of pages18
ISBN (Print)9780470749968
StatePublished - Aug 31 2010


  • Cell adherence to ECM lattice - for cell migration
  • Cells, and meshwork of proteins and proteoglycans - and extracellular matrix (ECM)
  • Collagen secreted by fibroblasts - into ECM as single polypeptide chains
  • ECM manipulation - during tumor development
  • ECM, for maintaining tissue integrity and stability - survival, polarity, proliferation, transcription and migration
  • ECM, providing structural support, shape and tissue stability
  • Extracellular matrix contributions - to tumorigenesis
  • Fibrils arranged in specific patterns - forming ECM, fibronectin and elastic fibers binding
  • Fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ)
  • Fibulin-5 and tumor development

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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