Contiguous Meningioma and B-Cell Lymphoma: A Scoping Review and Case Illustration

William H. Hicks, Mark N. Pernik, Emmanuel Adeyemo, John Mathews, Alex J. Pildain, Russell Payne

Research output: Contribution to journalReview articlepeer-review


Background: The diagnosis of a contiguous, synchronous meningioma and central nervous system B-cell lymphoma is rare and associated with paradoxical treatment paradigms. We performed a scoping review of contiguous meningioma and B-cell lymphoma and included an additional illustrative case. Methods: The OVID Medline and PubMed databases were systematically searched using the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. Only human clinical reports of contiguous, synchronous meningioma and B-cell lymphoma were included. We concurrently detailed a representative case from our institution. Results: Nine case reports met our criteria, including the present case. The average age at diagnosis was 67.4 years. Patients showed a female-to-male predominance of 7:2. The diagnosis of synchronous intracranial tumors was not suspected or discovered until after surgical resection in 100% of cases. All meningiomas were grade I on histopathologic diagnosis, while lymphomas were distributed between diffuse large B-cell lymphoma (56%), metastatic lymphoma (22%), Burkitt lymphoma (11%), and follicular lymphoma (11%). All patients underwent surgical resection. Patients (n = 5) treated with adjuvant chemotherapy had evidence of longer progression-free survival (median 12 months; range, 3–18 months) than patients without adjuvant chemotherapy (n = 2; median 2 months; range, 1–3 months). Conclusions: Contiguous, synchronous meningioma/B-cell lymphoma is a rare diagnosis that may appear as an inconspicuous solitary intracranial neoplasm on imaging. Based on the limited cases and current treatment of lymphoma, progression-free survival may be contingent on the prompt initiation of chemotherapy targeting the lymphoma rather than surgical resection of the meningeal mass. Providers should prioritize prompt medical management.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalWorld neurosurgery
StatePublished - Feb 2022


  • B-cell lymphoma
  • Meningioma
  • Multiple intracranial neoplasms
  • Neuro-oncology
  • Scoping review

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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