Context is key: Modulated protein multivalency in disease

Mikayla Eppert; Benjamin R. Sabari

doi:10.1016/j.molcel.2022.10.011

Context is key: Modulated protein multivalency in disease

Mikayla Eppert, Benjamin R. Sabari

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

In this issue of Molecular Cell, Song et al. demonstrate that mutations to the YEATS domain of ENL aberrantly activate gene expression by forming condensates on specific genomic loci. By using diverse experimental approaches, the authors dissect the molecular underpinnings of ENL mutant condensate formation.

Original language	English (US)
Pages (from-to)	3965-3967
Number of pages	3
Journal	Molecular cell
Volume	82
Issue number	21
DOIs	https://doi.org/10.1016/j.molcel.2022.10.011
State	Published - Nov 3 2022

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2022.10.011

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title = "Context is key: Modulated protein multivalency in disease",

abstract = "In this issue of Molecular Cell, Song et al. demonstrate that mutations to the YEATS domain of ENL aberrantly activate gene expression by forming condensates on specific genomic loci. By using diverse experimental approaches, the authors dissect the molecular underpinnings of ENL mutant condensate formation.",

author = "Mikayla Eppert and Sabari, {Benjamin R.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = nov,

day = "3",

doi = "10.1016/j.molcel.2022.10.011",

language = "English (US)",

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journal = "Molecular cell",

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T2 - Modulated protein multivalency in disease

AU - Eppert, Mikayla

AU - Sabari, Benjamin R.

PY - 2022/11/3

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N2 - In this issue of Molecular Cell, Song et al. demonstrate that mutations to the YEATS domain of ENL aberrantly activate gene expression by forming condensates on specific genomic loci. By using diverse experimental approaches, the authors dissect the molecular underpinnings of ENL mutant condensate formation.

AB - In this issue of Molecular Cell, Song et al. demonstrate that mutations to the YEATS domain of ENL aberrantly activate gene expression by forming condensates on specific genomic loci. By using diverse experimental approaches, the authors dissect the molecular underpinnings of ENL mutant condensate formation.

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DO - 10.1016/j.molcel.2022.10.011

M3 - Comment/debate

C2 - 36332603

AN - SCOPUS:85140999027

SN - 1097-2765

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SP - 3965

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JO - Molecular cell

JF - Molecular cell

IS - 21

ER -

Context is key: Modulated protein multivalency in disease

Abstract

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