Contemporary Management of Severely Calcified Coronary Lesions

Natthapon Angsubhakorn, Nicolas Kang, Colleen Fearon, Chol Techorueangwiwat, Pooja Swamy, Emmanouil S. Brilakis, Aditya S. Bharadwaj

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Coronary artery calcification is increasingly prevalent in our patient population. It significantly limits the procedural success of percutaneous coronary intervention and is associated with a higher risk of adverse cardiovascular events both in the short-term and long-term. There are several modalities for modifying calcified plaque, such as balloon angioplasty (including specialty balloons), coronary atheroablative therapy (rotational, orbital, and laser atherectomy), and intravascular lithotripsy. We discuss each modality’s relative advantages and disadvantages and the data supporting their use. This review also highlights the importance of intravascular imaging to characterize coronary calcification and presents an algorithm to tailor the calcium modification therapy based on specific coronary lesion characteristics.

Original languageEnglish (US)
Article number1638
JournalJournal of Personalized Medicine
Issue number10
StatePublished - Oct 2022
Externally publishedYes


  • coronary artery calcification
  • intravascular imaging
  • percutaneous coronary intervention

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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