Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Michele Carbone; Ivano Amelio; El Bachir Affar; James Brugarolas; Lisa A. Cannon-Albright; Lewis C. Cantley; Webster K. Cavenee; Zhijian Chen; Carlo M. Croce; Alan D’ Andrea; David Gandara; Carlotta Giorgi; Wei Jia; Qing Lan; Tak Wah Mak; James L. Manley; Katsuhiko Mikoshiba; Jose N. Onuchic; Harvey I. Pass; Paolo Pinton; Carol Prives; Nathaniel Rothman; Said M. Sebti; James Turkson; Xifeng Wu; Haining Yang; Herbert Yu; Gerry Melino

doi:10.1038/s41418-018-0213-5

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Michele Carbone, Ivano Amelio, El Bachir Affar, James Brugarolas, Lisa A. Cannon-Albright, Lewis C. Cantley, Webster K. Cavenee, Zhijian Chen, Carlo M. Croce, Alan D’ Andrea, David Gandara, Carlotta Giorgi, Wei Jia, Qing Lan, Tak Wah Mak, James L. Manley, Katsuhiko Mikoshiba, Jose N. Onuchic, Harvey I. Pass, Paolo PintonCarol Prives, Nathaniel Rothman, Said M. Sebti, James Turkson, Xifeng Wu, Haining Yang, Herbert Yu, Gerry Melino

Research output: Contribution to journal › Review article › peer-review

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Abstract

The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene–environment interactions (G x E) arise when the combined presence of both a germline genetic variant and a known environmental factor modulates the risk of disease more than either one alone. A panel of experts discussed our current understanding of cancer aetiology, known examples of G × E interactions in cancer, and the expanded concept of G × E interactions to include somatic cancer mutations and iatrogenic environmental factors such as anti-cancer treatment. Specific genetic polymorphisms and genetic mutations increase susceptibility to certain carcinogens and may be targeted in the near future for prevention and treatment of cancer patients with novel molecularly based therapies. There was general consensus that a better understanding of the complexity and numerosity of G × E interactions, supported by adequate technological, epidemiological, modelling and statistical resources, will further promote our understanding of cancer and lead to novel preventive and therapeutic approaches.

Original language	English (US)
Pages (from-to)	1885-1904
Number of pages	20
Journal	Cell Death and Differentiation
Volume	25
Issue number	11
DOIs	https://doi.org/10.1038/s41418-018-0213-5
State	Published - Nov 1 2018

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., ... Melino, G. (2018). Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death and Differentiation, 25(11), 1885-1904. https://doi.org/10.1038/s41418-018-0213-5

Carbone, M, Amelio, I, Affar, EB, Brugarolas, J, Cannon-Albright, LA, Cantley, LC, Cavenee, WK, Chen, Z, Croce, CM, Andrea, AD, Gandara, D, Giorgi, C, Jia, W, Lan, Q, Mak, TW, Manley, JL, Mikoshiba, K, Onuchic, JN, Pass, HI, Pinton, P, Prives, C, Rothman, N, Sebti, SM, Turkson, J, Wu, X, Yang, H, Yu, H & Melino, G 2018, 'Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine', Cell Death and Differentiation, vol. 25, no. 11, pp. 1885-1904. https://doi.org/10.1038/s41418-018-0213-5

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title = "Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine",

abstract = "The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene–environment interactions (G x E) arise when the combined presence of both a germline genetic variant and a known environmental factor modulates the risk of disease more than either one alone. A panel of experts discussed our current understanding of cancer aetiology, known examples of G × E interactions in cancer, and the expanded concept of G × E interactions to include somatic cancer mutations and iatrogenic environmental factors such as anti-cancer treatment. Specific genetic polymorphisms and genetic mutations increase susceptibility to certain carcinogens and may be targeted in the near future for prevention and treatment of cancer patients with novel molecularly based therapies. There was general consensus that a better understanding of the complexity and numerosity of G × E interactions, supported by adequate technological, epidemiological, modelling and statistical resources, will further promote our understanding of cancer and lead to novel preventive and therapeutic approaches.",

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AU - Pinton, Paolo

AU - Prives, Carol

AU - Rothman, Nathaniel

AU - Sebti, Said M.

AU - Turkson, James

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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

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