TY - JOUR
T1 - Conjunctival involvement with T-cell prolymphocytic leukemia
T2 - Report of a case and review of the literature
AU - Lee, Susan S.
AU - Robinson, Michael R.
AU - Morris, John C.
AU - Mirtsching, Barry C.
AU - Shen, DeFen
AU - Chan, Chi Chao
PY - 2004
Y1 - 2004
N2 - T-cell prolymphocytic leukemia is a rare and highly aggressive hematological neoplasm. A patient with T-cell prolymphocytic leukemia presented with bilateral perilimbal conjunctival infiltrates. Conjunctival biopsy showed aggregates of large atypical lymphocytes in the substantia propria with a concentration of atypical cells in the perivascular areas. Immunophenotyping of the malignant cells identified an abnormal clonal T-cell population consistent with T-cell prolymphocytic leukemia. A literature review of all reports of conjunctival involvement with leukemia was performed. The three cases of ocular prolymphocytic leukemia, including the one case of ocular T-cell prolymphocytic leukemia, are discussed in detail as well as 14 reported clinical cases of biopsy-proven conjunctival leukemia. The majority of cases occurred in the setting of acute leukemia, and conjunctival involvement was frequently a presenting sign of the disease or signified disease relapse. Conjunctival involvement with leukemia was consistent with good visual acuity; however, it portended a poor prognosis.
AB - T-cell prolymphocytic leukemia is a rare and highly aggressive hematological neoplasm. A patient with T-cell prolymphocytic leukemia presented with bilateral perilimbal conjunctival infiltrates. Conjunctival biopsy showed aggregates of large atypical lymphocytes in the substantia propria with a concentration of atypical cells in the perivascular areas. Immunophenotyping of the malignant cells identified an abnormal clonal T-cell population consistent with T-cell prolymphocytic leukemia. A literature review of all reports of conjunctival involvement with leukemia was performed. The three cases of ocular prolymphocytic leukemia, including the one case of ocular T-cell prolymphocytic leukemia, are discussed in detail as well as 14 reported clinical cases of biopsy-proven conjunctival leukemia. The majority of cases occurred in the setting of acute leukemia, and conjunctival involvement was frequently a presenting sign of the disease or signified disease relapse. Conjunctival involvement with leukemia was consistent with good visual acuity; however, it portended a poor prognosis.
KW - T cell
KW - conjunctiva
KW - immunohistochemistry
KW - prolymphocytic leukemia
KW - therapy
UR - http://www.scopus.com/inward/record.url?scp=7444231160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7444231160&partnerID=8YFLogxK
U2 - 10.1016/j.survophthal.2004.06.005
DO - 10.1016/j.survophthal.2004.06.005
M3 - Article
C2 - 15325197
AN - SCOPUS:7444231160
SN - 0039-6257
VL - 49
SP - 525
EP - 536
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
IS - 5
ER -