TY - JOUR
T1 - Congenital bilateral cataracts in newborns exposed to elexacaftor-tezacaftor-ivacaftor in utero and while breast feeding
AU - Jain, Raksha
AU - Wolf, Alvit
AU - Molad, Michal
AU - Taylor-Cousar, Jennifer
AU - Jr, Charles R.Esther
AU - Shteinberg, Michal
N1 - Funding Information:
We acknowledge with gratitude the Israeli CF foundation for funding provided for this work.
Publisher Copyright:
© 2022
PY - 2022/11
Y1 - 2022/11
N2 - Elexacaftor-tezacaftor-ivacaftor (ETI) is known to pass through the placenta and into breast milk in mothers who continue on this therapy while pregnant and breast feeding. Toxicity studies of ivacaftor in rats demonstrated infant cataracts, but cataracts were not reported in human infants exposed to ivacaftor. We describe 3 cases of infants exposed to elexacaftor-tezacaftor-ivacaftor (ETI) in utero and while breast feeding who were found to have bilateral congenital cataracts within six months of birth. None of the infants had significant visual impairment from the cataracts nor any report of elevated liver function testing. These data highlight the need to counsel females who continue ETI throughout pregnancy and while breast feeding to consider cataract screen for their infants.
AB - Elexacaftor-tezacaftor-ivacaftor (ETI) is known to pass through the placenta and into breast milk in mothers who continue on this therapy while pregnant and breast feeding. Toxicity studies of ivacaftor in rats demonstrated infant cataracts, but cataracts were not reported in human infants exposed to ivacaftor. We describe 3 cases of infants exposed to elexacaftor-tezacaftor-ivacaftor (ETI) in utero and while breast feeding who were found to have bilateral congenital cataracts within six months of birth. None of the infants had significant visual impairment from the cataracts nor any report of elevated liver function testing. These data highlight the need to counsel females who continue ETI throughout pregnancy and while breast feeding to consider cataract screen for their infants.
KW - Breast feeding
KW - Cataract
KW - Elexacaftor-tezacaftor-ivacaftor
KW - Pregnant
UR - http://www.scopus.com/inward/record.url?scp=85140718064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85140718064&partnerID=8YFLogxK
U2 - 10.1016/j.jcf.2022.10.004
DO - 10.1016/j.jcf.2022.10.004
M3 - Article
C2 - 36266182
AN - SCOPUS:85140718064
SN - 1569-1993
VL - 21
SP - 1074
EP - 1076
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 6
ER -