Confabulation, amnesia and motor memory loss as a presentation of apparent ITPR1 antibody autoimmune encephalitis

Julia R. Schiff, Benjamin P. Fiorillo, Raha Sadjadi, Tracey L. Henry, Judah K. Gruen, Lauren M. Gensler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A 59-year-old woman presented to the hospital with acute, hypoactive altered mental status. Her symptoms had begun 3 days prior when she developed hallucinations, urinary and faecal incontinence, and somnolence. She also exhibited confabulations, amnesia, motor memory loss and a wide-based gait. Medical, psychiatric and neurological evaluations including imaging and laboratory workup were unrevealing. Treatment for possible Wernicke encephalopathy and psychosis with high-dose intravenous thiamine and antipsychotic medications did not lead to improvement. After discharge, a send-out cerebrospinal fluid autoimmune encephalitis panel resulted positive for the newly identified neuronal inositol triphosphate receptor one (ITPR1) antibody. This prompted readmission for intravenous steroids, plasmapheresis and intravenous immunoglobulin, which yielded mild clinical improvement. Here, we describe confabulations and psychiatric symptoms as novel manifestations of the primary presentation of anti-ITPR1 encephalitis in an effort to promote faster recognition of this disease and early initiation of treatment in suspected cases.

Original languageEnglish (US)
JournalBMJ Case Reports
Issue number9
StatePublished - Sep 16 2021
Externally publishedYes


  • immunology
  • neurology
  • psychiatry

ASJC Scopus subject areas

  • Medicine(all)


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