Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

C. C T Smith; A. P. Wilson; B. N C Prichard; D. J. Betteridge; W. Meade Th.; S. Dyer; G. H. Tofler; D. Brezinski; A. I. Schafer; A. Czeisler Ch.; J. D. Rutherford; N. Willich St.; R. E. Gleason; G. H. Williams; J. E. Muller

doi:10.1056/NEJM198712313172712

Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

C. C T Smith, A. P. Wilson, B. N C Prichard, D. J. Betteridge, W. Meade Th., S. Dyer, G. H. Tofler, D. Brezinski, A. I. Schafer, A. Czeisler Ch., J. D. Rutherford, N. Willich St., R. E. Gleason, G. H. Williams, J. E. Muller

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: Tofler et al. suggest that morning increases in plasma epinephrine and norepinephrine may contribute to increased platelet aggregation (June 11 issue).¹ There is no doubt that by themselves (high concentrations) or in synergistic association with other agonists (low concentrations), catecholamines promote platelet aggregation in vitro.² ³ ⁴ ⁵ However, we think that in vivo not only plasma catecholamines but also platelet catecholamines may have a role in the development of coronary heart disease. Thus, the likelihood of having a myocardial infarction may also depend on a patient's platelet catecholamine levels. Indeed, in studies in patients with pheochromocytoma, Zweifler and Romero…

Original language	English (US)
Pages (from-to)	1736-1737
Number of pages	2
Journal	New England Journal of Medicine
Volume	317
Issue number	27
DOIs	https://doi.org/10.1056/NEJM198712313172712
State	Published - Dec 31 1987

ASJC Scopus subject areas

General Medicine

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10.1056/NEJM198712313172712

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Smith, C. C. T., Wilson, A. P., Prichard, B. N. C., Betteridge, D. J., Meade Th., W., Dyer, S., Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler Ch., A., Rutherford, J. D., Willich St., N., Gleason, R. E., Williams, G. H., & Muller, J. E. (1987). Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death. New England Journal of Medicine, 317(27), 1736-1737. https://doi.org/10.1056/NEJM198712313172712

Smith, CCT, Wilson, AP, Prichard, BNC, Betteridge, DJ, Meade Th., W, Dyer, S, Tofler, GH, Brezinski, D, Schafer, AI, Czeisler Ch., A, Rutherford, JD, Willich St., N, Gleason, RE, Williams, GH & Muller, JE 1987, 'Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death', New England Journal of Medicine, vol. 317, no. 27, pp. 1736-1737. https://doi.org/10.1056/NEJM198712313172712

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title = "Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death",

abstract = "To the Editor: Tofler et al. suggest that morning increases in plasma epinephrine and norepinephrine may contribute to increased platelet aggregation (June 11 issue).1 There is no doubt that by themselves (high concentrations) or in synergistic association with other agonists (low concentrations), catecholamines promote platelet aggregation in vitro.2 3 4 5 However, we think that in vivo not only plasma catecholamines but also platelet catecholamines may have a role in the development of coronary heart disease. Thus, the likelihood of having a myocardial infarction may also depend on a patient's platelet catecholamine levels. Indeed, in studies in patients with pheochromocytoma, Zweifler and Romero…",

author = "Smith, {C. C T} and Wilson, {A. P.} and Prichard, {B. N C} and Betteridge, {D. J.} and {Meade Th.}, W. and S. Dyer and Tofler, {G. H.} and D. Brezinski and Schafer, {A. I.} and {Czeisler Ch.}, A. and Rutherford, {J. D.} and {Willich St.}, N. and Gleason, {R. E.} and Williams, {G. H.} and Muller, {J. E.}",

year = "1987",

month = dec,

day = "31",

doi = "10.1056/NEJM198712313172712",

language = "English (US)",

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AU - Smith, C. C T

AU - Wilson, A. P.

AU - Prichard, B. N C

AU - Betteridge, D. J.

AU - Meade Th., W.

AU - Dyer, S.

AU - Tofler, G. H.

AU - Brezinski, D.

AU - Schafer, A. I.

AU - Czeisler Ch., A.

AU - Rutherford, J. D.

AU - Willich St., N.

AU - Gleason, R. E.

AU - Williams, G. H.

AU - Muller, J. E.

PY - 1987/12/31

Y1 - 1987/12/31

N2 - To the Editor: Tofler et al. suggest that morning increases in plasma epinephrine and norepinephrine may contribute to increased platelet aggregation (June 11 issue).1 There is no doubt that by themselves (high concentrations) or in synergistic association with other agonists (low concentrations), catecholamines promote platelet aggregation in vitro.2 3 4 5 However, we think that in vivo not only plasma catecholamines but also platelet catecholamines may have a role in the development of coronary heart disease. Thus, the likelihood of having a myocardial infarction may also depend on a patient's platelet catecholamine levels. Indeed, in studies in patients with pheochromocytoma, Zweifler and Romero…

AB - To the Editor: Tofler et al. suggest that morning increases in plasma epinephrine and norepinephrine may contribute to increased platelet aggregation (June 11 issue).1 There is no doubt that by themselves (high concentrations) or in synergistic association with other agonists (low concentrations), catecholamines promote platelet aggregation in vitro.2 3 4 5 However, we think that in vivo not only plasma catecholamines but also platelet catecholamines may have a role in the development of coronary heart disease. Thus, the likelihood of having a myocardial infarction may also depend on a patient's platelet catecholamine levels. Indeed, in studies in patients with pheochromocytoma, Zweifler and Romero…

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Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

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