TY - JOUR
T1 - Concentrations of polychlorinated biphenyls and organochlorine pesticides in umbilical cord blood serum of newborns in Kingston, Jamaica
AU - Rahbar, Mohammad H.
AU - Samms-Vaughan, Maureen
AU - Hessabi, Manouchehr
AU - Dickerson, Aisha S.
AU - Lee, Min Jae
AU - Bressler, Jan
AU - Tomechko, Sara E.
AU - Moreno, Emily K.
AU - Loveland, Katherine A.
AU - Desai, Charlene Coore
AU - Shakespeare-Pellington, Sydonnie
AU - Reece, Jody Ann
AU - Morgan, Renee
AU - Geiger, Matthew J.
AU - O’Keefe, Michael E.
AU - Grove, Megan L.
AU - Boerwinkle, Eric
N1 - Funding Information:
This research is co-funded by the National Institute of Environmental Health Sciences (NIEHS) by a grant (R01ES022165), as well as the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Fogarty International Center (NIH-FIC) by a grant (R21HD057808) awarded to University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Jamaican Birth Cohort (JA Kids) Study, supported by a grant from Inter-American Development Bank (IDB) Project Number (ATN/JF-12312-JA) awarded to the University of the West Indies, Mona Campus, in Jamaica. Moreover, we acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is mainly funded by the NIH Centers for Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to University of Texas Health Science Center at Houston in 2006 by the National Center for Research Resources (NCRR) and its renewal (UL1 TR000371) by the National Center for Advancing Translational Sciences (NCATS). Furthermore, we acknowledge that the collection and management of survey data were done using REDCap [25], which was partly supported by a grant (UL1 TR000445) from NCATS/NIH, awarded to Vanderbilt University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NICHD, NIH-FIC, NIEHS, NCRR, IDB or NCATS. Furthermore, we acknowledge contributions by Ms. Samantha Foote related to data entry into the REDCap database from Jamaica. Finally, we acknowledge contributions by colleagues in the Analytical Chemistry Lab at MDHHS for analyzing and storing the cord blood serum samples for the assessments of PCB and OC pesticide concentrations, under a service contract.
Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - To date much of the biomonitoring related to exposure to polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is from middle to high income countries, including the U.S., Canada and Europe, but such data are lacking for the majority of low to middle income countries. Using data from 64 pregnant mothers who were enrolled in 2011, we aimed to assess the concentrations of the aforementioned toxins in umbilical cord blood serum of 67 Jamaican newborns. For 97 of the 100 PCB congeners and 16 of the 17 OC pesticides, all (100%) concentrations were below their respective limits of detection (LOD). Mean (standard deviation (SD)) lipid-adjusted concentrations in cord blood serum for congeners PCB-153, PCB-180, PCB-206 and total PCB were 14.25 (3.21), 7.16 (1.71), 7.30 (1.74) and 28.15 (6.03) ng/g-lipid, respectively. The means (SD) for the 4,4′-dichlorodiphenyldichloroethylene (DDE)-hexane fraction and total-DDE were 61.61 (70.78) and 61.60 (70.76) ng/g-lipid, respectively. Compared to the U.S. and Canada, the concentrations of these toxins were lower in cord-blood serum of Jamaican newborns. We discuss that these differences could be partly due to differences in dietary patterns in these countries. Despite limitations in our dataset, our results provide information on the investigated toxins in cord blood serum that could serve as a reference for Jamaican newborns.
AB - To date much of the biomonitoring related to exposure to polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is from middle to high income countries, including the U.S., Canada and Europe, but such data are lacking for the majority of low to middle income countries. Using data from 64 pregnant mothers who were enrolled in 2011, we aimed to assess the concentrations of the aforementioned toxins in umbilical cord blood serum of 67 Jamaican newborns. For 97 of the 100 PCB congeners and 16 of the 17 OC pesticides, all (100%) concentrations were below their respective limits of detection (LOD). Mean (standard deviation (SD)) lipid-adjusted concentrations in cord blood serum for congeners PCB-153, PCB-180, PCB-206 and total PCB were 14.25 (3.21), 7.16 (1.71), 7.30 (1.74) and 28.15 (6.03) ng/g-lipid, respectively. The means (SD) for the 4,4′-dichlorodiphenyldichloroethylene (DDE)-hexane fraction and total-DDE were 61.61 (70.78) and 61.60 (70.76) ng/g-lipid, respectively. Compared to the U.S. and Canada, the concentrations of these toxins were lower in cord-blood serum of Jamaican newborns. We discuss that these differences could be partly due to differences in dietary patterns in these countries. Despite limitations in our dataset, our results provide information on the investigated toxins in cord blood serum that could serve as a reference for Jamaican newborns.
KW - Jamaica
KW - Kingston
KW - Newborns
KW - Organochlorine (OC) pesticides
KW - Polychlorinated biphenyls (PCBs)
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U2 - 10.3390/ijerph13101032
DO - 10.3390/ijerph13101032
M3 - Article
C2 - 27775677
AN - SCOPUS:84992398716
SN - 1661-7827
VL - 13
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 10
M1 - 1032
ER -