@inproceedings{d28dd3b236c447d1b79567ea1f772885,
title = "Computerized segmentation algorithm with personalized atlases of murine MRIs in a SV40 Large T-antigen mouse mammary cancer model",
abstract = "Quantities of MRI data, much larger than can be objectively and efficiently analyzed manually, are routinely generated in preclinical research. We aim to develop an automated image segmentation and registration pipeline to aid in analysis of image data from our high-throughput 9.4 Tesla small animal MRI imaging center. T2-weighted, fat-suppressed MRIs were acquired over 4 life-cycle time-points [up to 12 to 18 weeks] of twelve C3(1) SV40 Large T-antigen mice for a total of 46 T2-weighted MRI volumes; each with a matrix size of 192 x 256, 62 slices, in plane resolution 0.1 mm, and slice thickness 0.5 mm. These image sets were acquired with the goal of tracking and quantifying progression of mammary intraepithelial neoplasia (MIN) to invasive cancer in mice, believed to be similar to ductal carcinoma in situ (DCIS) in humans. Our segmentation algorithm takes 2D seed-points drawn by the user at the center of the 4 coregistered volumes associated with each mouse. The level set then evolves in 3D from these 2D seeds. The contour evolution incorporates texture information, edge information, and a statistical shape model in a two-step process. Volumetric DICE coefficients comparing the automatic with manual segmentations were computed and ranged between 0.75 and 0.58 for averages over the 4 life-cycle time points of the mice. Incorporation of these personalized atlases with intra and inter mouse registration is expected to enable locally and globally tracking of the morphological and textural changes in the mammary tissue and associated lesions of these mice.",
keywords = "Breast cancer, Ductal carcinoma in situ, Image analysis, MRI, Mammary intraepithelial neoplasia, Murine mammary gland, Preclinical, Radiomics",
author = "Sibley, {Adam R.} and Erica Markiewicz and Devkumar Mustafi and Xiaobing Fan and Suzanne Conzen and Greg Karczmar and Giger, {Maryellen L.}",
note = "Funding Information: Supported, in part, by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under grant number T32 EB002103, National Institutes of Health (R01-CA133490 and R01-CA167785), Lynn S. Florsheim Foundation, Segal Foundation, and VPH prism grant from the European Union. Publisher Copyright: {\textcopyright} 2016 SPIE.; Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 01-03-2016 Through 03-03-2016",
year = "2016",
doi = "10.1117/12.2217425",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Barjor Gimi and Andrzej Krol",
booktitle = "Medical Imaging 2016",
}