Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT-AF Registry

Alexander C. Perino, Peter Shrader, Mintu P. Turakhia, Jack E. Ansell, Bernard J. Gersh, Gregg C. Fonarow, Alan S. Go, Daniel W. Kaiser, Elaine M. Hylek, Peter R. Kowey, Daniel E. Singer, Laine Thomas, Benjamin A. Steinberg, Eric D. Peterson, Jonathan P. Piccini, Kenneth W. Mahaffey

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Patient satisfaction with therapy is an important metric of care quality and has been associated with greater medication persistence. We evaluated the association of patient satisfaction with warfarin therapy to other metrics of anticoagulation care quality and clinical outcomes among patients with atrial fibrillation (AF). Methods and Results: Using data from the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) registry, patients were identified with AF who were taking warfarin and had completed an Anti-Clot Treatment Scale (ACTS) questionnaire, a validated metric of patient-reported burden and benefit of oral anticoagulation. Multivariate regressions were used to determine association of ACTS burden and benefit scores with time in therapeutic international normalized ratio range (TTR; both ≥75% and ≥60%), warfarin discontinuation, and clinical outcomes (death, stroke, major bleed, and all-cause hospitalization). Among 1514 patients with AF on warfarin therapy (75±10 years; 42% women; CHA2DS2-VASc 3.9±1.7), those most burdened with warfarin therapy were younger and more likely to be women, have paroxysmal AF, and to be treated with antiarrhythmic drugs. After adjustment for covariates, ACTS burden scores were independent of TTR (TTR ≥75%: odds ratio, 1.01 [95% CI, 0.99–1.03]; TTR ≥60%: odds ratio, 1.01 [95% CI, 0.98–1.05]), warfarin discontinuation (odds ratio, 0.99; 95% CI, 0.97–1.01), or clinical outcomes. ACTS benefit scores were also not associated with TTR, warfarin discontinuation, or clinical outcomes. Conclusions: In a large registry of patients with AF taking warfarin, ACTS scores provided independent information beyond other traditional metrics of oral anticoagulation care quality and identified patient groups at high risk for dissatisfaction with warfarin therapy.

Original languageEnglish (US)
Article numbere011205
JournalJournal of the American Heart Association
Issue number9
StatePublished - May 7 2019
Externally publishedYes


  • anticoagulation
  • atrial fibrillation
  • patient-centered care
  • patient-reported outcome
  • warfarin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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