TY - JOUR
T1 - Comparative analysis of zymogen granule membrane polypeptides
AU - MacDonald, Raymond J.
AU - Ronzio, Robert A.
N1 - Funding Information:
Acknowledgments: This research was supported in part by a USPHSG rant GM-17773. R. J. M. was supported by USPHST raining Grant GM-1091. R. A. R. is a Research Career Development Awardee from the USPHS( Grant HD-70309). This is a Journal Article No. 6040 from the Michigan Agricultural Fzperiment Station.
PY - 1972/10/17
Y1 - 1972/10/17
N2 - Polypeptides of zymogen granule membranes from rat, beef, dog, pig, and rabbit pancreas were analyzed by polyacrylamide gel electrophoresis in 1% sodium dodecylsulfate. Granule membranes were characterized by a single major polypeptide species detected by the periodic acid-Schiff procedure. The relative mobilities of this component were similar for these mammals. The component was distinct from major polypeptides of mitochondrial or microsomal membranes. The zymogen granule membrane may, therefore, represent a highly specialized intracellular membrane.
AB - Polypeptides of zymogen granule membranes from rat, beef, dog, pig, and rabbit pancreas were analyzed by polyacrylamide gel electrophoresis in 1% sodium dodecylsulfate. Granule membranes were characterized by a single major polypeptide species detected by the periodic acid-Schiff procedure. The relative mobilities of this component were similar for these mammals. The component was distinct from major polypeptides of mitochondrial or microsomal membranes. The zymogen granule membrane may, therefore, represent a highly specialized intracellular membrane.
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U2 - 10.1016/0006-291X(72)90421-4
DO - 10.1016/0006-291X(72)90421-4
M3 - Article
C2 - 4640364
AN - SCOPUS:0015514156
SN - 0006-291X
VL - 49
SP - 377
EP - 382
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -