Abstract
Aim The prognostic effects of chemotherapy and various lymph node measures [positive nodes, total node count and the positive lymph node ratio (PLNR)] have been established. It is unknown whether the cancer-specific survival benefit of chemotherapy differs across these nodal prognostic categories. Method This retrospective analysis of linked Surveillance, Epidemiology and End Results (SEER) data and Medicare data (SEER-Medicare)included patients ≥ 65years of age with a diagnosis of stage III colon cancer between 1997 and 2002. We grouped patients according to the number of positive nodes (N1 and N2), total node count (≥12 and <12 total nodes) and PLNR (below the 75th percentile and at least at the 75th percentile of the PLNR). The end point was colon cancer-specific mortality. Results Fifty-one per cent (3701) of the 7263 patients received adjuvant therapy during the time period 1997-2002. The mean (standard deviation) number of total nodes examined was 13 (9) and the number of positive nodes identified was 3 (3). Patients with N2 disease, <12 total nodes examined and a high PLNR had a worse survival at 2, 3 and 5years following colectomy. Utilization of chemotherapy demonstrated a colon cancer-specific survival benefit (hazard ratio at median follow up=0.7; P<0.001) that was consistent and statistically significant across the three nodal prognostic categories examined. Conclusion The benefit of chemotherapy did not vary based on N stage, total node count or PLNR. The results favour a broad-based approach towards increasing the chemotherapy treatment rates in stage III patients of ≥ 65years of age, rather than an approach that targets clinical subgroups.
Original language | English (US) |
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Pages (from-to) | 48-55 |
Number of pages | 8 |
Journal | Colorectal Disease |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2012 |
Keywords
- Chemotherapy
- Colon cancer
- Node ratio
- Positive nodes
- Survival
ASJC Scopus subject areas
- Gastroenterology