Comorbidity of Psychopathological Domains in Community-Dwelling Persons with Alzheimer's Disease

Rochelle E. Tractenberg, Myron F. Weiner, Marian B. Patterson, Linda Teri, Leon J. Thal

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


In this post hoc analysis of baseline responses to the CERAD Behavior Rating Scale for Dementia in a clinical trial of interventions for agitation in Alzheimer's disease (AD), the authors investigated the distribution of, and relationships between, agitation, depression, and psychosis in 148 individuals with AD. Prevalence of depressive symptoms was highest (78.4%), followed by agitation (77.6%) and psychotic symptoms (69.3%); 51.1% of the sample had symptoms in all 3 domains. Cross-sectionally, psychotic symptoms were most closely associated with Mini-Mental State Examination (MMSE) scores, while agitation was less so. Depressive symptoms were relatively consistently prevalent across MMSE levels. After controlling for the presence of agitated symptoms, psychosis and depression were significantly associated, but neither symptoms of psychosis nor of depression were associated with agitation when depression or psychosis, respectively, was controlled for. Significant psychopathological comorbidity should be considered in the design of clinical trials targeting particular psychopathology in this disease population.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
JournalJournal of Geriatric Psychiatry and Neurology
Issue number2
StatePublished - Jun 2003


  • Agitation
  • Alzheimer's
  • Comorbidity
  • Depression
  • Psychopathology
  • Psychosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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