Abstract
NF-κB is a master transcriptional regulator of inflammation that plays an important role in oncogenesis, particularly in tumors that arise in the context of inflammation. Copper metabolism MURR1 domain-containing 1 (COMMD1) is a negative regulator of NF-κB. Recent genetic-based studies in both mice and human patients indicate that COMMD1 has an important role in controlling intestinal inflammation and constraining progression to colitis-associated cancer.
Original language | English (US) |
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Article number | e947891 |
Journal | OncoImmunology |
Volume | 3 |
Issue number | 7 |
DOIs | |
State | Published - 2014 |
Keywords
- COMMD1
- Colitis-associated cancer
- Inflammation
- Inflammatory bowel disease
- NF-κB
- Ubiquitination
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology