TY - JOUR
T1 - Combined modality therapy
T2 - Is it necessary for everyone?
AU - Porembka, Matthew R.
AU - Weiser, Martin R.
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Survival and relapse in rectal cancer are intimately associated with disease stage. Although surgery remains the primary treatment modality for rectal cancer, its limitations as an isolated curative treatment are well recognized. Trimodality therapy combining surgery, chemotherapy, and radiation has improved local recurrence rates and survival in patients with advanced rectal tumors (T3/4) or those with nodal involvement (N1/2). With the broad application of trimodality therapy, concern for over-treatment in select groups of patients exists. Current investigations are now focused on identifying subsets of favorable-risk patients who may benefit from tailored therapy and reducing exposure to unnecessary treatment-related risk.
AB - Survival and relapse in rectal cancer are intimately associated with disease stage. Although surgery remains the primary treatment modality for rectal cancer, its limitations as an isolated curative treatment are well recognized. Trimodality therapy combining surgery, chemotherapy, and radiation has improved local recurrence rates and survival in patients with advanced rectal tumors (T3/4) or those with nodal involvement (N1/2). With the broad application of trimodality therapy, concern for over-treatment in select groups of patients exists. Current investigations are now focused on identifying subsets of favorable-risk patients who may benefit from tailored therapy and reducing exposure to unnecessary treatment-related risk.
UR - http://www.scopus.com/inward/record.url?scp=84883032045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883032045&partnerID=8YFLogxK
U2 - 10.1053/j.scrs.2013.03.008
DO - 10.1053/j.scrs.2013.03.008
M3 - Article
AN - SCOPUS:84883032045
SN - 1043-1489
VL - 24
SP - 151
EP - 154
JO - Seminars in Colon and Rectal Surgery
JF - Seminars in Colon and Rectal Surgery
IS - 3
ER -