TY - JOUR
T1 - Combinatorial roles of the nuclear receptor corepressor in transcription and development
AU - Jepsen, Kristen
AU - Hermanson, Ola
AU - Onami, Thandi M.
AU - Gleiberman, Anatoli S.
AU - Lunyak, Victoria
AU - McEvilly, Robert J.
AU - Kurokawa, Riki
AU - Kumar, Vivek
AU - Liu, Forrest
AU - Seto, Edward
AU - Hedrick, Stephen M.
AU - Mandel, Gail
AU - Glass, Christopher K.
AU - Rose, David W.
AU - Rosenfeld, Michael G.
N1 - Funding Information:
We thank V. Perissi and S. H. Baek for dominant-negative HDAC3; B. S. Katzenellenbogen for CMV-ER; R. McKay for nestin antibodies; J. D. Marth for R1 ES cells; A. Krones and T. Herman for sequencing; M. Frazer and H. Taylor for animal care; A. Hazra and C. Nelson for assistance; M. Fisher for help in preparing the manuscript; P. Meyer for preparation of the figures; B. Andersen for useful discussions; and A. K. Ryan for comments on the manuscript. This research was supported by grants to D. W. R. (NIH 1 RO1 DK54802-O1A1); E. S., S. M. H., G. M., and C. K. G. (NIH); and M. G. R. (NIH, CAPCURE, and California Cancer Research Program).
PY - 2000/9/15
Y1 - 2000/9/15
N2 - Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF. Unexpectedly, N-CoR and a specific deacetylase were also required for transcriptional activation of one class of retinoic acid response element. Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems.
AB - Transcriptional repression plays crucial roles in diverse aspects of metazoan development, implying critical regulatory roles for corepressors such as N-CoR and SMRT. Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice and the resulting block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF. Unexpectedly, N-CoR and a specific deacetylase were also required for transcriptional activation of one class of retinoic acid response element. Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems.
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U2 - 10.1016/S0092-8674(00)00064-7
DO - 10.1016/S0092-8674(00)00064-7
M3 - Article
C2 - 11030619
AN - SCOPUS:0034664769
SN - 0092-8674
VL - 102
SP - 753
EP - 763
JO - Cell
JF - Cell
IS - 6
ER -