TY - JOUR
T1 - Collective activation of MRI agents via encapsulation and disease-triggered release
AU - Viger, Mathieu L.
AU - Sankaranarayanan, Jagadis
AU - De Gracia Lux, Caroline
AU - Chan, Minnie
AU - Almutairi, Adah
PY - 2013/5/29
Y1 - 2013/5/29
N2 - An activation mechanism based on encapsulated ultrasmall gadolinium oxide nanoparticles (Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response to chemical markers of disease (i.e., acidic pH, H2O2) is presented. Inside the hydrophobic polymeric matrices, the Gd oxide NPs are shielded from the aqueous environment, silencing their ability to enhance water proton relaxation. Upon disassembly of the polymeric particles, activation of multiple contrast agents generates a strong positive contrast enhancement of >1 order of magnitude.
AB - An activation mechanism based on encapsulated ultrasmall gadolinium oxide nanoparticles (Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response to chemical markers of disease (i.e., acidic pH, H2O2) is presented. Inside the hydrophobic polymeric matrices, the Gd oxide NPs are shielded from the aqueous environment, silencing their ability to enhance water proton relaxation. Upon disassembly of the polymeric particles, activation of multiple contrast agents generates a strong positive contrast enhancement of >1 order of magnitude.
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U2 - 10.1021/ja403167p
DO - 10.1021/ja403167p
M3 - Article
C2 - 23672342
AN - SCOPUS:84878402641
SN - 0002-7863
VL - 135
SP - 7847
EP - 7850
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 21
ER -