Cognitive patterns in school-age children with end-stage liver disease

S. M. Stewart, R. A. Campbell, D. McCallon, D. A. Waller, W. S. Andrews

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Although children with end-stage liver disease (ESLD) have been found to have cognitive delays, the relationship between patterns of cognitive function and diagnostic category, age of onset, duration and severity of disease has not been assessed before transplantation. Verbal and performance IQ (VIQ, PIQ) scores and scores on Bannatyne's cognitive factors for 43 children with ESLD were compared with those of 15 control children with cystic fibrosis (CF) and with existing normative data. Children with biliary atresia had deficits in PIQ, spatial and sequential scores. Children with α-1 antitrypsin deficiency did not differ significantly from CF controls but did show deficits compared with normative data. Children with onset of disease in the first year of life had deficits on all cognitive measures compared with both control groups. In contrast, children with later onset differed from the normative population only on VIQ and the acquired knowledge factor. In multiple regression analyses, duration of disease and indexes of liver dysfunction combine to predict cognitive scores. These preliminary findings suggest that children with early onset of liver disease are at high risk for cognitive impairment. J Dev Behav Pediatr 13:331–338, 1992. Index terms: Children, liver disease, cognitive patterns, IQ.

Original languageEnglish (US)
Pages (from-to)331-338
Number of pages8
JournalJournal of Developmental and Behavioral Pediatrics
Issue number5
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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