TY - JOUR
T1 - Cognitive flexibility in verbal and nonverbal domains and decision making in anorexia nervosa patients
T2 - A pilot study
AU - Abbate-Daga, Giovanni
AU - Buzzichelli, Sara
AU - Amianto, Federico
AU - Rocca, Giuseppe
AU - Marzola, Enrica
AU - McClintock, Shawn M.
AU - Fassino, Secondo
N1 - Funding Information:
We would like to thank Dr. Kate Tchanturia for her interest in our study and her precious advice. This study was supported by the Piedmont Region of Italy with research founding for new treatments for Anorexia Nervosa (July 2009 notification). We have no financial conflicts or other relationships that could be interpreted as a conflict of interest affecting this manuscript.
PY - 2011/10/7
Y1 - 2011/10/7
N2 - Background: This paper aimed to investigate cognitive rigidity and decision making impairments in patients diagnosed with Anorexia Nervosa Restrictive type (AN-R), assessing also verbal components.Methods: Thirty patients with AN-R were compared with thirty age-matched healthy controls (HC). All participants completed a comprehensive neuropsychological battery comprised of the Trail Making Test, Wisconsin Card Sorting Test, Hayling Sentence Completion Task, and the Iowa Gambling Task. The Beck Depression Inventory was administered to evaluate depressive symptomatology. The influence of both illness duration and neuropsychological variables was considered. Body Mass Index (BMI), years of education, and depression severity were considered as covariates in statistical analyses. Results: The AN-R group showed poorer performance on all neuropsychological tests. There was a positive correlation between illness duration and the Hayling Sentence Completion Task Net score, and number of completion answers in part B. There was a partial effect of years of education and BMI on neuropsychological test performance. Response inhibition processes and verbal fluency impairment were not associated with BMI and years of education, but were associated with depression severity.Conclusions: These data provide evidence that patients with AN-R have cognitive rigidity in both verbal and non-verbal domains. The role of the impairment on verbal domains should be considered in treatment. Further research is warranted to better understand the relationship between illness state and cognitive rigidity and impaired decision-making.
AB - Background: This paper aimed to investigate cognitive rigidity and decision making impairments in patients diagnosed with Anorexia Nervosa Restrictive type (AN-R), assessing also verbal components.Methods: Thirty patients with AN-R were compared with thirty age-matched healthy controls (HC). All participants completed a comprehensive neuropsychological battery comprised of the Trail Making Test, Wisconsin Card Sorting Test, Hayling Sentence Completion Task, and the Iowa Gambling Task. The Beck Depression Inventory was administered to evaluate depressive symptomatology. The influence of both illness duration and neuropsychological variables was considered. Body Mass Index (BMI), years of education, and depression severity were considered as covariates in statistical analyses. Results: The AN-R group showed poorer performance on all neuropsychological tests. There was a positive correlation between illness duration and the Hayling Sentence Completion Task Net score, and number of completion answers in part B. There was a partial effect of years of education and BMI on neuropsychological test performance. Response inhibition processes and verbal fluency impairment were not associated with BMI and years of education, but were associated with depression severity.Conclusions: These data provide evidence that patients with AN-R have cognitive rigidity in both verbal and non-verbal domains. The role of the impairment on verbal domains should be considered in treatment. Further research is warranted to better understand the relationship between illness state and cognitive rigidity and impaired decision-making.
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U2 - 10.1186/1471-244X-11-162
DO - 10.1186/1471-244X-11-162
M3 - Article
C2 - 21982555
AN - SCOPUS:80053606811
SN - 1471-244X
VL - 11
JO - BMC Psychiatry
JF - BMC Psychiatry
M1 - 162
ER -