@article{964e51478aa342a4ae166195d62cdf97,
title = "Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy",
abstract = "Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.",
author = "Millan, {Mark J.} and Yves Agid and Martin Br{\"u}ne and Bullmore, {Edward T.} and Carter, {Cameron S.} and Clayton, {Nicola S.} and Richard Connor and Sabrina Davis and Bill Deakin and Derubeis, {Robert J.} and Bruno Dubois and Geyer, {Mark A.} and Goodwin, {Guy M.} and Philip Gorwood and Jay, {Th{\'e}r{\`e}se M.} and Marian Jo{\"e}ls and Mansuy, {Isabelle M.} and Andreas Meyer-Lindenberg and Declan Murphy and Edmund Rolls and Bernd Saletu and Michael Spedding and John Sweeney and Miles Whittington and Young, {Larry J.}",
note = "Funding Information: M. Soubeyran is thanked for excellent secretarial assistance, S.-M. Rivet for the excellent graphics, and A. Gobert and A. Dekeyne are likewise thanked for their logistical help. We would like to thank three anonymous reviewers for their insightful comments that helped to improve the manuscript. This paper emerged from a Congress that took place in France, 2009, organized by {\textquoteleft}Advances in Neuroscience for Medical Innovation{\textquoteright} and supported by an educational grant from Institut de Recherche Servier.",
year = "2012",
month = feb,
doi = "10.1038/nrd3628",
language = "English (US)",
volume = "11",
pages = "141--168",
journal = "Nature Reviews Drug Discovery",
issn = "1474-1776",
publisher = "Nature Publishing Group",
number = "2",
}