Cloning, sequence, and tissue distribution of a rabbit renal Na+/H+ exchanger transcript

Friedhelm Hildebrandt, John H. Pizzonia, Robert F. Reilly, Nancy A. Rebouças, Claude Sardet, Jacques Pouysségur, Carolyn W. Slayman, Peter S. Aronson, Peter Igarashi

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Rabbit kidney expresses a transcript that is similar to the human growth-factor-activatable Na+/H+ exchanger. PCR and library screening were used to clone overlapping 2.5 kb, 1.4 kb, and 1.8 kb cDNAs that together contain the entire coding region (2448 bp) and 5′ untranslated region (726 bp) and part of the 3′ untranslated region (128 bp) of a rabbit renal Na+/H+ exchanger transcript. The nucleotide and inferred amino acid sequences are highly conserved between rabbit and human (88% nucleotide identity, 95% amino acid identity). In rabbit, the transcript is expressed in both epithelial and non-epithelial tissues, with highes expression in stomach, brain, kidney, lung and ileum, and minimal expression in liver and skeletal muscle.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalBBA - Gene Structure and Expression
Issue number1
StatePublished - Dec 2 1991


  • (Rabbit kidney)
  • Amino acid sequence
  • Polymerase chain reaction
  • Sodium-proton exchange
  • cDNA cloning

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics


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