A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2.
|Original language||English (US)|
|Number of pages||5|
|Journal||Biochimica et Biophysica Acta - Gene Structure and Expression|
|State||Published - Apr 12 2002|
- Nuclear localization signal
ASJC Scopus subject areas
- Structural Biology