Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis

Flavia G. Nunes Rosado, Charles W. Stratton, Claudio A. Mosse

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Context.-Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. Objective.-To assess and compare the histopathologic and epidemiologic features of common and uncommon pediatric bacterial lymphadenitis. Design.-We searched our database for surgical specimens that had a positive identification of bacteria during an 8-year period. The chart was reviewed to assess the pathogen identified and epidemiologic data. The archival tissue sections were reviewed and the histopathologic findings described for each pathogen. Results.-The review of 368 pediatric lymph node biopsies identified 33 cases with a bacterial infection. These comprised 21 cases of Mycobacterium avium complex (60%), 1 of Mycobacterium fortuitum (3%), 7 of Bartonella henselae (20%), 2 of Yersinia enterocolitica (7%), 1 of Francisella tularensis (3%) and 1 of Streptococcus pyogenes (3%). Conclusions.-Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report.

Original languageEnglish (US)
Pages (from-to)1490-1493
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number11
StatePublished - Nov 2011
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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