@article{9e84ef49e030483d8dd1d05049ced309,
title = "Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association{\textquoteright}s Get With The Guidelines Registry",
abstract = "As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hospitalized with COVID-19 at centers participating in the American Heart Association{\textquoteright}s COVID-19 CVD Registry. The primary outcome was odds of enrollment in a clinical trial, according to sex, race, and ethnicity. Among 14,397 adults hospitalized with COVID-19, 9.5% (n = 1,377) were enrolled in a clinical trial. The proportion of enrolled patients was the lowest for Black patients (8%); in multivariable analysis, female and Black patients were less likely to be enrolled in a clinical trial related to COVID-19 compared to men and other racial groups, respectively. Determination of specific reasons for the disparities in trial participation related to COVID-19 in these populations should be further investigated.",
keywords = "COVID-19, Disparities, Ethnicity, Race",
author = "Shah, {Kevin S.} and Reyes-Miranda, {Adriana E.} and Bradley, {Steven M.} and Khadijah Breathett and Das, {Sandeep R.} and Gluckman, {Ty J.} and Divya Gupta and Leung, {Daniel T.} and Mutharasan, {R. Kannan} and Peterson, {Pamela N.} and Spivak, {Emily S.} and Shah, {Rashmee U.}",
note = "Funding Information: The authors are indebted to the Get With The Guidelines{\textregistered} programs, which are provided by the American Heart Association. The American Heart Association Precision Medicine Platform ( https://precision.heart.org/ ) was used for data analysis. IQVIA (Parsippany, New Jersey) serves as the data collection and coordination center. The AHA{\textquoteright}s suite of Registries is funded by multiple industry sponsors. The AHA COVID-19 CVD Registry is partially supported by The Gordon and Betty Moore Foundation. KSS reports grant funding from The University of Utah Immunology, Inflammation & Infectious Disease initiative. KB has research funding National Heart, Lung, and Blood Institute (NHLBI) K01HL142848, R25HL126146 subaward 11692sc, and L30HL148881; University of Arizona Health Sciences, Strategic Priorities Faculty Initiative Grant; and University of Arizona, Sarver Heart Center, Novel Research Project Award in the Area of Cardiovascular Disease and Medicine, Anthony and Mary Zoia Research Award; and Women as One. RUS reports grant funding from Women as One. Publisher Copyright: {\textcopyright} 2022, W. Montague Cobb-NMA Health Institute.",
year = "2022",
doi = "10.1007/s40615-022-01277-8",
language = "English (US)",
volume = "10",
pages = "892--898",
journal = "Journal of racial and ethnic health disparities",
issn = "2197-3792",
publisher = "Springer Nature",
number = "2",
}