Clinical recognition and management of depression in node negative breast cancer patients treated with tamoxifen

Cynthia K. Cathcart, Stephen E. Jones, C. Sue Pumroy, George N. Peters, Sally M. Knox, J. Harold Cheek

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Depression is not an uncommon complaint of women with breast cancer and is usually assumed to be related to the cancer diagnosis itself or its treatment. As part of a prospective clinical trial of adjuvant therapy of node negative breast cancer, 301 patients treated and assessed by one oncologist (SEJ) were serially questioned for symptoms of depression in the first 6-12 months after completing initial treatment (surgery, radiation therapy, and/or chemotherapy). Two hundred and fifty-seven patients were evaluable for assessment of depression; 155 were receiving tamoxifen and 102 were not. Twenty-six patients had symptoms of depression including 23 (15%) treated with tamoxifen compared to 3 (3%) in the group not placed on tamoxifen (p < 0.005). Of the 23 patients with depression in the tamoxifen group, symptoms were temporally related to the initiation of therapy and occurred generally in the first 2 months of treatment. Eight patients had mild symptoms not requiring a dose reduction, 8 had significant depression requiring a dose reduction to relieve symptoms, and 7 required discontinuation of tamoxifen. We conclude that clinical depression as a side effect of tamoxifen therapy may be more common than previously believed and should be further rigorously investigated to confirm or deny our clinical impressions.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalBreast Cancer Research and Treatment
Issue number3
StatePublished - Jan 1993


  • antiestrogens
  • breast cancer
  • depression
  • tamoxifen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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