Clinical Presentation, Diagnosis, and Pathogenesis of Dementia With Lewy Bodies

Dementia with Lewy bodies is a neurodegenerative disorder typified by progressive cognitive decline with associated visual hallucinations, fluctuations in awareness, parkinsonism, and rapid eye movement sleep behavior disorder. The diagnosis can be difficult to make and requires a detailed interview, identification of characteristic signs on neurological examination, and diagnostic testing when atypical features are present. This article delves into the salient features of the disorder, highlighting the neuropsychiatric spectrum of clinical manifestations, emerging disease biomarkers, and the role of ancillary studies in the diagnosis. [Psychiatr Ann. 2022;52(10):398-403.].