Clinical pathological features and relativity of breast benign diseases and breast cancer

Objective: To analyze the clinical pathological features and relativity of breast benign diseases and breast cancer. Methods: The clinical pathological data of 2 222 cases of breast benign diseases and breast cancer were analysed retrospectively, and the ER expression in breast cancer's adjacent tissue was examined. Results: A total of 94. 8% of all breast benign diseases were proliferative breast diseases; 95.8% of all malignant cases were infiltrating cancer. The average age (47.1) of breast cancer was higher than that (34.9) of proliferative breast diseases, P<0.0001. The breast cancer risk for the patients with malignant family history was higher than that for those without malignant family history, P<0.001. Seventy-two percent of proliferative breast diseases appeared simultaneously more than three pathological elements. The incidence rate of AH in breast cancer adjacent tissue (23.5%)was much higher than that in pure proliferative breast lesion process (2.49%), P<0.01. ER appeared high expression in breast cancer and various lesions of breast cancer adjacent tissue. Conclusion: Proliferative breast disease is the most common breast benign disease with multi-lessions, and its process is related to breast cancer.