@inbook{1a10dae019474687a88e442385c07896,
title = "Clinical management",
abstract = "The final chapter of the fourth edition summarizes management of gestational hypertension with a focus on the preeclampsia syndrome. The importance of preeclampsia as a multisystem disorder is emphasized, with the goal of arriving at management interventions that are based on scientific observations that describe the pathophysiology of the syndrome. Over the past three decades there has been an unprecedented accrual of high-quality evidence-based studies that underpin clinical management of the woman and her fetus in pregnancies complicated by severe preeclampsia or eclampsia. In that regard, this chapter describes management principles that are based on many of the scientific and clinical observations elucidated in the preceding 19 chapters.",
keywords = "Eclampsia, Evidence-based management, Hypertension, Magnesium sulfate therapy, Preeclampsia",
author = "Alexander, {James M.} and {Gary Cunningham}, F.",
note = "Funding Information: The multinational Eclampsia Trial Collaborative Group study 100 was funded in part by the World Health Organization and coordinated by the National Perinatal Epidemiology Unit in Oxford, England. This study involved 1687 women with eclampsia who were randomly allocated to different anticonvulsant regimens. In one cohort, 453 women were randomly assigned to be given magnesium sulfate and compared with 452 given diazepam. In a second cohort, another 388 eclamptic women were randomly assigned to be given magnesium sulfate and compared with 387 women given phenytoin. The results of these and other comparative studies are discussed in detail in Chapter 12 and results summarized in Table 20.10 . In aggregate, magnesium sulfate therapy was associated with a significantly decreased rate of recurrent seizures – 9% versus 23% – and a lower maternal death rate – 3% versus 4.8% – when compared with either phenytoin or diazepam. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",
year = "2014",
month = jan,
day = "1",
doi = "10.1016/B978-0-12-407866-6.00020-1",
language = "English (US)",
pages = "439--464",
booktitle = "Chesley's Hypertensive Disorders in Pregnancy, Fourth Edition",
publisher = "Elsevier Science",
address = "United Kingdom",
}