Clinical magnetic resonance spectroscopy: A critical evaluation

R. E. Lenkinski

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The present status of magnetic resonance spectroscopy (MRS) in the clinical radiology setting is discussed critically. The number of groups reporting clinical MRS results has increased, indicating the feasibility of performing localized MRS studies on current 1.5 T whole body MR imagers. However the lack of high quality radiofrequency (RF) coils for MRS and proven user-independent methods for the analysis of spectral data is still hampering further development. At present there is no consensus as to the optimal localization scheme which should be employed for phosphorus (31P) MRS. For proton MRS the stimulated echo sequence is gaining wide acceptance. The minimum voxel sizes achievable for proton and31P MRS in the brain are calculated to be 2 and 30 cm3, respectively. The recent results obtained with proton decoupling for31P clearly demonstrate that there is a great deal of improvement possible in the quality of localized31P spectra at 1.5 T. Both the instrument manufacturers and researchers in the field face important challenges in translating methods which have proven feasibility in the research environment into routine clinical protocols.

Original languageEnglish (US)
Pages (from-to)1034-1038
Number of pages5
JournalInvestigative Radiology
Issue number12
StatePublished - Dec 1989


  • Clinical
  • Magnetic
  • Resonance
  • Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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