Clinical importance of the cytochromes P450

Daniel W. Nebert; David W. Russell

doi:10.1016/S0140-6736(02)11203-7

Clinical importance of the cytochromes P450

Daniel W. Nebert, David W. Russell

Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

1140 Scopus citations

Abstract

The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D₃ synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.

Original language	English (US)
Pages (from-to)	1155-1162
Number of pages	8
Journal	Lancet
Volume	360
Issue number	9340
DOIs	https://doi.org/10.1016/S0140-6736(02)11203-7
State	Published - Oct 12 2002

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(02)11203-7

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title = "Clinical importance of the cytochromes P450",

abstract = "The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.",

author = "Nebert, {Daniel W.} and Russell, {David W.}",

note = "Funding Information: We thank our colleagues for valuable discussions and critical reading of this report; and Marian L Miller for help with the artwork. This work was funded, in part, by US National Institutes of Health (NIH) grants R01 ES06321, R01 ES08147, P30 ES06096 (DWN), and P50 HL20948 (DWR). The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report.",

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AU - Nebert, Daniel W.

AU - Russell, David W.

N1 - Funding Information: We thank our colleagues for valuable discussions and critical reading of this report; and Marian L Miller for help with the artwork. This work was funded, in part, by US National Institutes of Health (NIH) grants R01 ES06321, R01 ES08147, P30 ES06096 (DWN), and P50 HL20948 (DWR). The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report.

PY - 2002/10/12

Y1 - 2002/10/12

N2 - The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.

AB - The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.

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DO - 10.1016/S0140-6736(02)11203-7

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VL - 360

SP - 1155

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JO - Lancet

JF - Lancet

IS - 9340

ER -

Clinical importance of the cytochromes P450

Abstract

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