Classification of VWD

Jessica Garcia; Sandra L. Haberichter; Veronica H. Flood

doi:10.1002/9781119419525.ch7

Classification of VWD

Jessica Garcia, Sandra L. Haberichter, Veronica H. Flood

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Von Willebrand disease (VWD) is the most common inherited bleeding disorder, and one of the most complex. It is caused primarily by defects in the von Willebrand factor (VWF) protein, and can be divided into both quantitative and qualitative disorders. The current classification system considers type 1 VWD to represent the mild to moderate quantitative deficiencies of VWF, and type 3 VWD to represent the severe quantitative deficiency of VWF. Type 2 refers to the qualitative variants which are divided by VWF defect. Appropriate classification of VWD is important to determine the most appropriate treatment for affected patients.

Original language	English (US)
Title of host publication	Textbook of von Willebrand Disease
Subtitle of host publication	Basic and Clinical Aspects
Publisher	wiley
Pages	73-79
Number of pages	7
ISBN (Electronic)	9781119419525
ISBN (Print)	9781119419488
DOIs	https://doi.org/10.1002/9781119419525.ch7
State	Published - Jan 1 2024

Keywords

bleeding
factor VIII
genetics
platelets
Von Willebrand disease
von Willebrand factor

ASJC Scopus subject areas

General Medicine

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10.1002/9781119419525.ch7

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abstract = "Von Willebrand disease (VWD) is the most common inherited bleeding disorder, and one of the most complex. It is caused primarily by defects in the von Willebrand factor (VWF) protein, and can be divided into both quantitative and qualitative disorders. The current classification system considers type 1 VWD to represent the mild to moderate quantitative deficiencies of VWF, and type 3 VWD to represent the severe quantitative deficiency of VWF. Type 2 refers to the qualitative variants which are divided by VWF defect. Appropriate classification of VWD is important to determine the most appropriate treatment for affected patients.",

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AB - Von Willebrand disease (VWD) is the most common inherited bleeding disorder, and one of the most complex. It is caused primarily by defects in the von Willebrand factor (VWF) protein, and can be divided into both quantitative and qualitative disorders. The current classification system considers type 1 VWD to represent the mild to moderate quantitative deficiencies of VWF, and type 3 VWD to represent the severe quantitative deficiency of VWF. Type 2 refers to the qualitative variants which are divided by VWF defect. Appropriate classification of VWD is important to determine the most appropriate treatment for affected patients.

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KW - genetics

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ER -

Classification of VWD

Abstract

Keywords

ASJC Scopus subject areas

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