Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis

Xiaojiang Gao; Edward J. Ball; Lori Dombrausky; Nancy J. Olsen; Theodore Pincus; Muhammad Asim Khan; Frederick Wolfe; Peter Stastny

doi:10.1016/0002-9343(88)90373-7

Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis

Xiaojiang Gao, Edward J. Ball, Lori Dombrausky, Nancy J. Olsen, Theodore Pincus, Muhammad Asim Khan, Frederick Wolfe, Peter Stastny

Internal Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Human leukocyte antigen (HLA) typing was performed in 174 patients with rheumatoid arthritis and 222 white control subjects. Increases in HLA-DR4 and HLA-DR1 were observed as in previous studies. Each of these appeared to be inherited as dominant risk factors. Southern blotting with a DR-beta probe after digestion of genomic DNA with the restriction enzyme Bam HI showed seven bands. Three of them correlated with DR4 and were increased in rheumatoid arthritis patients. Subsets of DR4 were determined by polymerase chain reaction amplification followed by hybridization with oligonucleotide probes. Dw4 was increased in rheumatoid arthritis patients, and the frequency of the other subsets appeared to be similar in rheumatoid arthritis patients and control subjects. A polymorphism associated with the T cell receptor V-beta-8 gene family was significantly increased in rheumatoid arthritis patients.

Original language	English (US)
Pages (from-to)	14-16
Number of pages	3
Journal	The American Journal of Medicine
Volume	85
Issue number	6 SUPPL. 1
DOIs	https://doi.org/10.1016/0002-9343(88)90373-7
State	Published - Dec 23 1988

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General Medicine

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title = "Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis",

abstract = "Human leukocyte antigen (HLA) typing was performed in 174 patients with rheumatoid arthritis and 222 white control subjects. Increases in HLA-DR4 and HLA-DR1 were observed as in previous studies. Each of these appeared to be inherited as dominant risk factors. Southern blotting with a DR-beta probe after digestion of genomic DNA with the restriction enzyme Bam HI showed seven bands. Three of them correlated with DR4 and were increased in rheumatoid arthritis patients. Subsets of DR4 were determined by polymerase chain reaction amplification followed by hybridization with oligonucleotide probes. Dw4 was increased in rheumatoid arthritis patients, and the frequency of the other subsets appeared to be similar in rheumatoid arthritis patients and control subjects. A polymorphism associated with the T cell receptor V-beta-8 gene family was significantly increased in rheumatoid arthritis patients.",

author = "Xiaojiang Gao and Ball, {Edward J.} and Lori Dombrausky and Olsen, {Nancy J.} and Theodore Pincus and Khan, {Muhammad Asim} and Frederick Wolfe and Peter Stastny",

note = "Funding Information: From the Department of Internal Medicine, Univenity of Texas Southwestern Medical Center, Dallas, Texas; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee,; Cleveland Metropolitan General Hospital, Cleveland. Ohio; and Arthritis Center, Wichita, Kansas, This study was supported by National Institutes of Health grants 5.ROl-Al21278-05, 5-Wl-A123271-03, and l-P50-AR39169.01. Requests for reprints should be addressed to Dr. Peter Stastny, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boule. vard, Dallas, Texas 75235.",

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T1 - Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis

AU - Gao, Xiaojiang

AU - Ball, Edward J.

AU - Dombrausky, Lori

AU - Olsen, Nancy J.

AU - Pincus, Theodore

AU - Khan, Muhammad Asim

AU - Wolfe, Frederick

AU - Stastny, Peter

N1 - Funding Information: From the Department of Internal Medicine, Univenity of Texas Southwestern Medical Center, Dallas, Texas; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee,; Cleveland Metropolitan General Hospital, Cleveland. Ohio; and Arthritis Center, Wichita, Kansas, This study was supported by National Institutes of Health grants 5.ROl-Al21278-05, 5-Wl-A123271-03, and l-P50-AR39169.01. Requests for reprints should be addressed to Dr. Peter Stastny, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boule. vard, Dallas, Texas 75235.

PY - 1988/12/23

Y1 - 1988/12/23

N2 - Human leukocyte antigen (HLA) typing was performed in 174 patients with rheumatoid arthritis and 222 white control subjects. Increases in HLA-DR4 and HLA-DR1 were observed as in previous studies. Each of these appeared to be inherited as dominant risk factors. Southern blotting with a DR-beta probe after digestion of genomic DNA with the restriction enzyme Bam HI showed seven bands. Three of them correlated with DR4 and were increased in rheumatoid arthritis patients. Subsets of DR4 were determined by polymerase chain reaction amplification followed by hybridization with oligonucleotide probes. Dw4 was increased in rheumatoid arthritis patients, and the frequency of the other subsets appeared to be similar in rheumatoid arthritis patients and control subjects. A polymorphism associated with the T cell receptor V-beta-8 gene family was significantly increased in rheumatoid arthritis patients.

AB - Human leukocyte antigen (HLA) typing was performed in 174 patients with rheumatoid arthritis and 222 white control subjects. Increases in HLA-DR4 and HLA-DR1 were observed as in previous studies. Each of these appeared to be inherited as dominant risk factors. Southern blotting with a DR-beta probe after digestion of genomic DNA with the restriction enzyme Bam HI showed seven bands. Three of them correlated with DR4 and were increased in rheumatoid arthritis patients. Subsets of DR4 were determined by polymerase chain reaction amplification followed by hybridization with oligonucleotide probes. Dw4 was increased in rheumatoid arthritis patients, and the frequency of the other subsets appeared to be similar in rheumatoid arthritis patients and control subjects. A polymorphism associated with the T cell receptor V-beta-8 gene family was significantly increased in rheumatoid arthritis patients.

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Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis

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