Circulating angiogenic factors in singleton vs multiple-gestation pregnancies

Sharon E. Maynard, Tiffany A. Moore Simas, Matthew J. Solitro, Abraham Rajan, Sybil Crawford, Peter Soderland, Bruce A. Meyer

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Objective: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. Study Design: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded. Results: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks. Conclusion: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.

Original languageEnglish (US)
Pages (from-to)200.e1-200.e7
JournalAmerican journal of obstetrics and gynecology
Issue number2
StatePublished - Feb 2008


  • angiogenic proteins
  • multiple pregnancy
  • preeclampsia
  • twins

ASJC Scopus subject areas

  • Obstetrics and Gynecology


Dive into the research topics of 'Circulating angiogenic factors in singleton vs multiple-gestation pregnancies'. Together they form a unique fingerprint.

Cite this