Circular reasoning: microRNAs and cell-cycle control

Raghu R. Chivukula, Joshua T. Mendell

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


MicroRNAs (miRNAs) have attracted considerable attention because of their important roles in development, normal physiology, and disease states including cancer. Recent studies have identified specific miRNAs that regulate the cell cycle and have documented that the loss or gain of miRNA-mediated cell-cycle control contributes to malignancy. miRNAs regulate classic cell-cycle control pathways by directly targeting proteins such as E2F transcription factors, cyclin-dependent kinases (Cdks), cyclins and Cdk inhibitors. Moreover, from recent findings, it has been suggested that miRNAs themselves might be subject to cell-cycle dependent regulation. Together, these observations indicate that the reciprocal control of RNA silencing and the metazoan cell cycle impacts cellular behavior and disease.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalTrends in biochemical sciences
Issue number10
StatePublished - Oct 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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