Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat

Shin Yamazaki; Mutsumi Maruyama; Felino R A Cagampang; Shin Ichi T Inouye

doi:10.1016/0006-8993(94)90713-7

Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat

Shin Yamazaki, Mutsumi Maruyama, Felino R A Cagampang, Shin Ichi T Inouye

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3′,5′-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.

Original language	English (US)
Pages (from-to)	329-331
Number of pages	3
Journal	Brain Research
Volume	651
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(94)90713-7
State	Published - Jul 18 1994

Keywords

Circadian rhythm
Enzyme immunoassay
Rat
Suprachiasmatic nucleus
cAMP

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)90713-7

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title = "Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat",

abstract = "Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3′,5′-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.",

keywords = "Circadian rhythm, Enzyme immunoassay, Rat, Suprachiasmatic nucleus, cAMP",

author = "Shin Yamazaki and Mutsumi Maruyama and Cagampang, {Felino R A} and Inouye, {Shin Ichi T}",

note = "Funding Information: The authors would like to thank Miss Noriko Hiro-machi for technical help. The present work was supported in part by Project Research Grant 10 from Mitsubishi Kasei Institute of Life Sciences.",

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AU - Cagampang, Felino R A

AU - Inouye, Shin Ichi T

N1 - Funding Information: The authors would like to thank Miss Noriko Hiro-machi for technical help. The present work was supported in part by Project Research Grant 10 from Mitsubishi Kasei Institute of Life Sciences.

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N2 - Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3′,5′-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.

AB - Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3′,5′-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.

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KW - Enzyme immunoassay

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KW - Suprachiasmatic nucleus

KW - cAMP

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Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat

Abstract

Keywords

ASJC Scopus subject areas

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