Churg-Strauss syndrome in children: A clinical and pathologic review

Debra Boyer, Sara O. Vargas, Dubhfeasa Slattery, Yadira M. Rivera-Sanchez, Andrew A. Colin

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Churg-Strauss syndrome is a vasculitis accompanied by asthma and eosinophilia. It is generally considered a disease of adults; occurrence in children has been reported infrequently. Here we report 2 pediatric patients with Churg-Strauss syndrome manifesting with prominent pulmonary involvement. One, a 16-year-old with a previous history of asthma, presented with pleuritic chest pain and a peripheral pulmonary nodule complicated by an eosinophilic pleural effusion. The other patient presented at age 6 with cough, weight loss, and radiographic infiltrates. Lung biopsies revealed elements characteristic of Churg-Strauss syndrome, including eosinophilic microabscesses and vasculitis. Three- and 5-year follow-up showed continued symptoms in both patients despite medical therapy. Both patients illustrate many of the typical features of Churg-Strauss syndrome. We report these cases to expand the scant knowledge about Churg-Strauss syndrome in pediatric patients and to heighten awareness that this serious disease may affect the pediatric population. The relevant literature on Churg-Strauss syndrome, with specific reference to childhood cases, is reviewed.

Original languageEnglish (US)
Pages (from-to)e914-e920
Issue number3
StatePublished - Sep 2006


  • Churg-Strauss syndrome
  • Eosinophilia
  • Pediatric
  • Pulmonary

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Churg-Strauss syndrome in children: A clinical and pathologic review'. Together they form a unique fingerprint.

Cite this