Chronic troponin elevation assessed by myocardial T1 mapping in patients with stable coronary artery disease

Carlos Alexandre W. Segre, James A. De Lemos, Antonildes Nascimento Assunção Junior, Cesar Higa Nomura, Desiderio Favarato, Celia Maria Cassaro Strunz, Alexandre Volney Villa, Jose Rodrigues Parga Filho, Paulo Cury Rezende, Whady Hueb, Jose Antonio Franchini Ramires, Roberto Kalil Filho, Carlos Vicente Serrano Junior

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Cardiac troponin detected with sensitive assays can be chronically elevated, in the absence of unstable coronary syndromes. In patients with chronic coronary artery disease, clinically silent ischemic episodes may cause chronic troponin release. T1 mapping is a cardiovascular magnetic resonance technique useful in quantitative cardiac tissue characterization. We selected patients with anatomically and functionally normal hearts to investigate associations between chronic troponin release and myocardial tissue characteristics assessed by T1 mapping. Methods: We investigated the relationship between cardiac troponin I concentrations and cardiovascular magnetic resonance T1 mapping parameters in patients with stable coronary artery disease enrolled in MASS V study before elective revascularization. Participants had no previous myocardial infarction, negative late gadolinium enhancement, normal left ventricular function, chamber dimensions and wall thickness. Results: A total of 56 patients were analyzed in troponin tertiles: nativeT1 and extracellular volume (ECV) values (expressed as means ± standard deviations) increased across tertiles: nativeT1 (1006 ± 27 ms vs 1016 ± 27 ms vs 1034 ± 37 ms, ptrend = 0.006) and ECV (22 ± 3% vs 23 ± 1.9% vs 25 ± 3%, ptrend = 0.007). Cardiac troponin I concentrations correlated with native T1(R = 0.33, P = .012) and ECV (R = 0.3, P = .025), and were independently associated with nativeT1 (P = .049) and ventricular mass index (P = .041) in multivariable analysis. Conclusion: In patients with chronic coronary artery disease and structurally normal hearts, troponin I concentrations correlated with T1 mapping parameters, suggesting that diffuse edema or fibrosis scattered in normal myocardium might be associated with chronic troponin release.

Original languageEnglish (US)
Pages (from-to)E33548
JournalMedicine (United States)
Volume102
Issue number16
DOIs
StatePublished - Apr 21 2023
Externally publishedYes

Keywords

  • T1 mapping
  • cardiac troponin
  • cardiovascular magnetic resonance (CMR)
  • chronic coronary artery disease
  • chronic troponin elevation
  • stable angina

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Chronic troponin elevation assessed by myocardial T1 mapping in patients with stable coronary artery disease'. Together they form a unique fingerprint.

Cite this