TY - JOUR
T1 - Chronic troponin elevation assessed by myocardial T1 mapping in patients with stable coronary artery disease
AU - Segre, Carlos Alexandre W.
AU - De Lemos, James A.
AU - Assunção Junior, Antonildes Nascimento
AU - Nomura, Cesar Higa
AU - Favarato, Desiderio
AU - Strunz, Celia Maria Cassaro
AU - Villa, Alexandre Volney
AU - Parga Filho, Jose Rodrigues
AU - Rezende, Paulo Cury
AU - Hueb, Whady
AU - Ramires, Jose Antonio Franchini
AU - Kalil Filho, Roberto
AU - Serrano Junior, Carlos Vicente
N1 - Funding Information:
Dr. de Lemos has received grant support from Roche Diagnostics and Abbott Diagnostics, and consulting income from Siemen Health Care Diagnostics, Ortho Clinical Diagnostics, and Quidel, Inc. He has been named a co-owner on a patent awarded to the University of Maryland (US Patent Application Number: 15/309,754) entitled: “Methods for Assessing Differential Risk for Developing Heart Failure.”
Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/4/21
Y1 - 2023/4/21
N2 - Background: Cardiac troponin detected with sensitive assays can be chronically elevated, in the absence of unstable coronary syndromes. In patients with chronic coronary artery disease, clinically silent ischemic episodes may cause chronic troponin release. T1 mapping is a cardiovascular magnetic resonance technique useful in quantitative cardiac tissue characterization. We selected patients with anatomically and functionally normal hearts to investigate associations between chronic troponin release and myocardial tissue characteristics assessed by T1 mapping. Methods: We investigated the relationship between cardiac troponin I concentrations and cardiovascular magnetic resonance T1 mapping parameters in patients with stable coronary artery disease enrolled in MASS V study before elective revascularization. Participants had no previous myocardial infarction, negative late gadolinium enhancement, normal left ventricular function, chamber dimensions and wall thickness. Results: A total of 56 patients were analyzed in troponin tertiles: nativeT1 and extracellular volume (ECV) values (expressed as means ± standard deviations) increased across tertiles: nativeT1 (1006 ± 27 ms vs 1016 ± 27 ms vs 1034 ± 37 ms, ptrend = 0.006) and ECV (22 ± 3% vs 23 ± 1.9% vs 25 ± 3%, ptrend = 0.007). Cardiac troponin I concentrations correlated with native T1(R = 0.33, P = .012) and ECV (R = 0.3, P = .025), and were independently associated with nativeT1 (P = .049) and ventricular mass index (P = .041) in multivariable analysis. Conclusion: In patients with chronic coronary artery disease and structurally normal hearts, troponin I concentrations correlated with T1 mapping parameters, suggesting that diffuse edema or fibrosis scattered in normal myocardium might be associated with chronic troponin release.
AB - Background: Cardiac troponin detected with sensitive assays can be chronically elevated, in the absence of unstable coronary syndromes. In patients with chronic coronary artery disease, clinically silent ischemic episodes may cause chronic troponin release. T1 mapping is a cardiovascular magnetic resonance technique useful in quantitative cardiac tissue characterization. We selected patients with anatomically and functionally normal hearts to investigate associations between chronic troponin release and myocardial tissue characteristics assessed by T1 mapping. Methods: We investigated the relationship between cardiac troponin I concentrations and cardiovascular magnetic resonance T1 mapping parameters in patients with stable coronary artery disease enrolled in MASS V study before elective revascularization. Participants had no previous myocardial infarction, negative late gadolinium enhancement, normal left ventricular function, chamber dimensions and wall thickness. Results: A total of 56 patients were analyzed in troponin tertiles: nativeT1 and extracellular volume (ECV) values (expressed as means ± standard deviations) increased across tertiles: nativeT1 (1006 ± 27 ms vs 1016 ± 27 ms vs 1034 ± 37 ms, ptrend = 0.006) and ECV (22 ± 3% vs 23 ± 1.9% vs 25 ± 3%, ptrend = 0.007). Cardiac troponin I concentrations correlated with native T1(R = 0.33, P = .012) and ECV (R = 0.3, P = .025), and were independently associated with nativeT1 (P = .049) and ventricular mass index (P = .041) in multivariable analysis. Conclusion: In patients with chronic coronary artery disease and structurally normal hearts, troponin I concentrations correlated with T1 mapping parameters, suggesting that diffuse edema or fibrosis scattered in normal myocardium might be associated with chronic troponin release.
KW - T1 mapping
KW - cardiac troponin
KW - cardiovascular magnetic resonance (CMR)
KW - chronic coronary artery disease
KW - chronic troponin elevation
KW - stable angina
UR - http://www.scopus.com/inward/record.url?scp=85153554267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85153554267&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000033548
DO - 10.1097/MD.0000000000033548
M3 - Article
C2 - 37083772
AN - SCOPUS:85153554267
SN - 0025-7974
VL - 102
SP - E33548
JO - Medicine (United States)
JF - Medicine (United States)
IS - 16
ER -