Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes

P. F. Kohler; R. E. Cronin; W. S. Hammond; D. Olin; R. I. Carr

doi:10.7326/0003-4819-81-4-448

Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes

P. F. Kohler, R. E. Cronin, W. S. Hammond, D. Olin, R. I. Carr

Internal Medicine

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102 Scopus citations

Abstract

The immunopathogenesis of chronic membranous glomerulonephritis was investigated in a 42 yr old man with chronic active hepatitis, type B. In 2 renal biopsies, 14 mth apart, immunofluorescent study showed glomerular deposition of the hepatitis B antigen (HB Ag) and host IgG, IgM, and C3 in an irregular ''immune complex'' pattern. Electron microscopy showed dense deposits in the thickened basement membrane but no morphologic evidence of the intact, spherical, 20 nm HB Ag. Low concentrations of HB Ag were found in serial serum samples whereas total complement and component concentrations were normal. Most significantly, circulating HB Ag antibody complexes were directly shown by serum cryoprecipitation. Results of in vitro tests for a cell mediated immune response to HB Ag were negative. The potential importance of chronic hepatitis B virus infection as a primary cause of human immune complex glomerulonephritis is supported by these findings.

Original language	English (US)
Pages (from-to)	448-451
Number of pages	4
Journal	Unknown Journal
Volume	81
Issue number	4
DOIs	https://doi.org/10.7326/0003-4819-81-4-448
State	Published - 1974

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Internal Medicine

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10.7326/0003-4819-81-4-448

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title = "Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes",

abstract = "The immunopathogenesis of chronic membranous glomerulonephritis was investigated in a 42 yr old man with chronic active hepatitis, type B. In 2 renal biopsies, 14 mth apart, immunofluorescent study showed glomerular deposition of the hepatitis B antigen (HB Ag) and host IgG, IgM, and C3 in an irregular ''immune complex'' pattern. Electron microscopy showed dense deposits in the thickened basement membrane but no morphologic evidence of the intact, spherical, 20 nm HB Ag. Low concentrations of HB Ag were found in serial serum samples whereas total complement and component concentrations were normal. Most significantly, circulating HB Ag antibody complexes were directly shown by serum cryoprecipitation. Results of in vitro tests for a cell mediated immune response to HB Ag were negative. The potential importance of chronic hepatitis B virus infection as a primary cause of human immune complex glomerulonephritis is supported by these findings.",

author = "Kohler, {P. F.} and Cronin, {R. E.} and Hammond, {W. S.} and D. Olin and Carr, {R. I.}",

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AU - Kohler, P. F.

AU - Cronin, R. E.

AU - Hammond, W. S.

AU - Olin, D.

AU - Carr, R. I.

PY - 1974

Y1 - 1974

N2 - The immunopathogenesis of chronic membranous glomerulonephritis was investigated in a 42 yr old man with chronic active hepatitis, type B. In 2 renal biopsies, 14 mth apart, immunofluorescent study showed glomerular deposition of the hepatitis B antigen (HB Ag) and host IgG, IgM, and C3 in an irregular ''immune complex'' pattern. Electron microscopy showed dense deposits in the thickened basement membrane but no morphologic evidence of the intact, spherical, 20 nm HB Ag. Low concentrations of HB Ag were found in serial serum samples whereas total complement and component concentrations were normal. Most significantly, circulating HB Ag antibody complexes were directly shown by serum cryoprecipitation. Results of in vitro tests for a cell mediated immune response to HB Ag were negative. The potential importance of chronic hepatitis B virus infection as a primary cause of human immune complex glomerulonephritis is supported by these findings.

AB - The immunopathogenesis of chronic membranous glomerulonephritis was investigated in a 42 yr old man with chronic active hepatitis, type B. In 2 renal biopsies, 14 mth apart, immunofluorescent study showed glomerular deposition of the hepatitis B antigen (HB Ag) and host IgG, IgM, and C3 in an irregular ''immune complex'' pattern. Electron microscopy showed dense deposits in the thickened basement membrane but no morphologic evidence of the intact, spherical, 20 nm HB Ag. Low concentrations of HB Ag were found in serial serum samples whereas total complement and component concentrations were normal. Most significantly, circulating HB Ag antibody complexes were directly shown by serum cryoprecipitation. Results of in vitro tests for a cell mediated immune response to HB Ag were negative. The potential importance of chronic hepatitis B virus infection as a primary cause of human immune complex glomerulonephritis is supported by these findings.

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Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes

Abstract

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