Chronic granulomatous invasive fungal sinusitis: An evolving approach to management

Ashleigh Halderman, Rabin Shrestha, Raj Sindwani

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Chronic granulomatous invasive fungal sinusitis (CGIFS) is rare and a consensus on ideal management is lacking. We present an extensive case managed successfully with a conservative approach. Methods: Case report and literature review. Results: The patient presented with unilateral proptosis, papilledema, and headache. Imaging revealed an infiltrative process with extensive intracranial and intraorbital involvement. Biopsy showed fungal elements and granulomatous reaction consistent with CGIFS. The patient was managed with conservative surgery and long-term oral voriconazole. Conclusion: This case supports a conservative surgical approach in some patients with extensive CGIFS. Oral voriconazole is effective and has significant advantages over more toxic agents administered intravenously.

Original languageEnglish (US)
Pages (from-to)280-283
Number of pages4
JournalInternational Forum of Allergy and Rhinology
Issue number4
StatePublished - Apr 2014


  • Aspergillus fumigatus
  • Fungus diseases
  • Papilledema
  • Sinusitis
  • Voriconazole

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology


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