Chromosome 12p abnormalities in dysgerminoma of the ovary: A FISH analysis

Paolo Cossu-Rocca, Shaobo Zhang, Lawrence M. Roth, John N. Eble, Wenxin Zheng, Fadi W. Abdul Karim, Helen Michael, Robert E. Emerson, Timothy D. Jones, Eyas M. Hattab, Liang Cheng

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Dysgerminoma is the most common malignant ovarian germ cell tumor and shares histological and immunophenotypical features with its testicular counterpart, seminoma. Chromosome 12p abnormalities are genetic hallmarks of testicular seminomas. Little is known about these genetic changes in dysgerminoma. We performed dual color fluorescence in situ hybridization (FISH) analyses with a centromeric α-satellite probe for chromosome 12 and a subtelomeric probe for 12p on paraffin-embedded tissue sections from 21 dysgerminomas and two gonadoblastomas. Chromosome 12p abnormalities were detected in 81% of dysgerminomas. In all, 57% of cases had only isochromosome 12p and 5% had only 12p overrepresentation. In all, 19% had both isochrome 12p and 12p overrepresentation. Gonadoblastomas were negative for isochromosome 12p or 12p overrepresentation. Chromosome 12p abnormalities are common in dysgerminoma of the ovary. FISH analyses for chromosome 12p abnormalities may be a useful diagnostic adjunct for confirming the diagnosis of dysgerminoma and for distinguishing it from nongerm cell malignancies that enter into the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)611-615
Number of pages5
JournalModern Pathology
Issue number4
StatePublished - Apr 2006


  • Dysgerminoma
  • Fluorescence in situ hybridization (FISH)
  • Germ cell tumors
  • Histogenesis
  • Isochromosome 12p
  • Ovarian neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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