TY - JOUR
T1 - Chromosomal rearrangements in a primary hepatocellular carcinoma
AU - Simon, Daniela
AU - Munoz, Santiago J.
AU - Maddrey, Willis C.
AU - Knowles, Barbara B.
N1 - Funding Information:
This work was supported by US Public Health Service Grants No. CA-37225 and CA-10815 from the National Cancer Institute.
PY - 1990/4
Y1 - 1990/4
N2 - Chromosome analysis of cells obtained at biopsy from a 65-year-old man with primary hepatocellular carcinoma revealed characteristic abnormalities of chromosomes 1, 5, 6, 9, 13, 16, and 22 in each cell and maintenance of a pseudodiploid chromosome number (46,XY). Five of the chromosomal sites involved in these rearrangements are either in fragile site regions or in regions containing genes that encode cellular oncogenes. Some of the tumor cells manifest mitotic deviations in the form of asynchronies, spiralization, premature centromere division, and non-sister chromatid associations. The significance of these findings to hepatocellular carcinogenesis is discussed.
AB - Chromosome analysis of cells obtained at biopsy from a 65-year-old man with primary hepatocellular carcinoma revealed characteristic abnormalities of chromosomes 1, 5, 6, 9, 13, 16, and 22 in each cell and maintenance of a pseudodiploid chromosome number (46,XY). Five of the chromosomal sites involved in these rearrangements are either in fragile site regions or in regions containing genes that encode cellular oncogenes. Some of the tumor cells manifest mitotic deviations in the form of asynchronies, spiralization, premature centromere division, and non-sister chromatid associations. The significance of these findings to hepatocellular carcinogenesis is discussed.
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U2 - 10.1016/0165-4608(90)90091-N
DO - 10.1016/0165-4608(90)90091-N
M3 - Article
C2 - 2156609
AN - SCOPUS:0025194967
SN - 0165-4608
VL - 45
SP - 255
EP - 260
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -