TY - JOUR
T1 - Chromatin-tethered MAPKs
AU - Klein, Aileen M.
AU - Zaganjor, Elma
AU - Cobb, Melanie H.
PY - 2013
Y1 - 2013
N2 - Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential nodes in many cellular regulatory circuits including those that take place on DNA. Most members of the four MAPK subgroups that exist in canonical three kinase cascades - extracellular signalregulated kinases 1 and 2 (ERK1/2), ERK5, c-Jun N-terminal kinases (JNK1-3), and p38 (α, β, γ, and δ) families - have been shown to perform regulatory functions on chromatin. This review offers a brief update on the variety of processes that involve MAPKs and available mechanisms garnered in the last two years.
AB - Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential nodes in many cellular regulatory circuits including those that take place on DNA. Most members of the four MAPK subgroups that exist in canonical three kinase cascades - extracellular signalregulated kinases 1 and 2 (ERK1/2), ERK5, c-Jun N-terminal kinases (JNK1-3), and p38 (α, β, γ, and δ) families - have been shown to perform regulatory functions on chromatin. This review offers a brief update on the variety of processes that involve MAPKs and available mechanisms garnered in the last two years.
UR - http://www.scopus.com/inward/record.url?scp=84877929954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877929954&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2013.01.002
DO - 10.1016/j.ceb.2013.01.002
M3 - Review article
C2 - 23434067
AN - SCOPUS:84877929954
SN - 0955-0674
VL - 25
SP - 272
EP - 277
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 2
ER -