Chloramphenicol and Gram-Negative Bacillary Meningitis in Neonates

William V. Shaw, V. Ausina, P. Coll, B. Mirelis, Jane D. Siegel, George H. Mccracken

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: In discussing chloramphenicol in the treatment of gram-negative bacillary meningitis in neonates in the March 12 issue, Siegel and McCracken1 state that “efficacy may be compromised by the emergence of resistance to chloramphenicol during the first 10 days of therapy in as many as 32 per cent of cases.” This is staggering news, and if true, it runs counter to the conventional wisdom that the “emergence” of resistance during the course of treatment of an infection occurs rarely and only when one or more of the following obtain: long duration of infection and treatment, large numbers of.

Original languageEnglish (US)
Pages (from-to)170-171
Number of pages2
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jul 16 1981

ASJC Scopus subject areas

  • Medicine(all)


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