TY - JOUR
T1 - Chloramphenicol and Gram-Negative Bacillary Meningitis in Neonates
AU - Shaw, William V.
AU - Ausina, V.
AU - Coll, P.
AU - Mirelis, B.
AU - Siegel, Jane D.
AU - Mccracken, George H.
PY - 1981/7/16
Y1 - 1981/7/16
N2 - To the Editor: In discussing chloramphenicol in the treatment of gram-negative bacillary meningitis in neonates in the March 12 issue, Siegel and McCracken1 state that “efficacy may be compromised by the emergence of resistance to chloramphenicol during the first 10 days of therapy in as many as 32 per cent of cases.” This is staggering news, and if true, it runs counter to the conventional wisdom that the “emergence” of resistance during the course of treatment of an infection occurs rarely and only when one or more of the following obtain: long duration of infection and treatment, large numbers of.
AB - To the Editor: In discussing chloramphenicol in the treatment of gram-negative bacillary meningitis in neonates in the March 12 issue, Siegel and McCracken1 state that “efficacy may be compromised by the emergence of resistance to chloramphenicol during the first 10 days of therapy in as many as 32 per cent of cases.” This is staggering news, and if true, it runs counter to the conventional wisdom that the “emergence” of resistance during the course of treatment of an infection occurs rarely and only when one or more of the following obtain: long duration of infection and treatment, large numbers of.
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U2 - 10.1056/NEJM198107163050318
DO - 10.1056/NEJM198107163050318
M3 - Letter
C2 - 7242591
AN - SCOPUS:0019467092
SN - 0028-4793
VL - 305
SP - 170
EP - 171
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 3
ER -